E-cadherin on epithelial–mesenchymal transition in thyroid cancer

Thyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of great significance to explore its mechanism and find action targets. Epithelial–mesenchymal tra...

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Detalles Bibliográficos
Autores principales: Zhu, Xiaoyu, Wang, Xiaoping, Gong, Yifei, Deng, Junlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690896/
https://www.ncbi.nlm.nih.gov/pubmed/34930256
http://dx.doi.org/10.1186/s12935-021-02344-6
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author Zhu, Xiaoyu
Wang, Xiaoping
Gong, Yifei
Deng, Junlin
author_facet Zhu, Xiaoyu
Wang, Xiaoping
Gong, Yifei
Deng, Junlin
author_sort Zhu, Xiaoyu
collection PubMed
description Thyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of great significance to explore its mechanism and find action targets. Epithelial–mesenchymal transition (EMT) is associated with tumor malignancy and invasion. One key change in tumour EMT is low expression of E-cadherin. Therefore, this article reviews the expression of E-cadherin in thyroid cancers (TC), discuss the potential mechanisms involved, and outline opportunities to exploit E-cadherin on regulating the occurrence of EMT as a critical factor in cancer therapeutics.
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spelling pubmed-86908962021-12-21 E-cadherin on epithelial–mesenchymal transition in thyroid cancer Zhu, Xiaoyu Wang, Xiaoping Gong, Yifei Deng, Junlin Cancer Cell Int Review Thyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of great significance to explore its mechanism and find action targets. Epithelial–mesenchymal transition (EMT) is associated with tumor malignancy and invasion. One key change in tumour EMT is low expression of E-cadherin. Therefore, this article reviews the expression of E-cadherin in thyroid cancers (TC), discuss the potential mechanisms involved, and outline opportunities to exploit E-cadherin on regulating the occurrence of EMT as a critical factor in cancer therapeutics. BioMed Central 2021-12-20 /pmc/articles/PMC8690896/ /pubmed/34930256 http://dx.doi.org/10.1186/s12935-021-02344-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhu, Xiaoyu
Wang, Xiaoping
Gong, Yifei
Deng, Junlin
E-cadherin on epithelial–mesenchymal transition in thyroid cancer
title E-cadherin on epithelial–mesenchymal transition in thyroid cancer
title_full E-cadherin on epithelial–mesenchymal transition in thyroid cancer
title_fullStr E-cadherin on epithelial–mesenchymal transition in thyroid cancer
title_full_unstemmed E-cadherin on epithelial–mesenchymal transition in thyroid cancer
title_short E-cadherin on epithelial–mesenchymal transition in thyroid cancer
title_sort e-cadherin on epithelial–mesenchymal transition in thyroid cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690896/
https://www.ncbi.nlm.nih.gov/pubmed/34930256
http://dx.doi.org/10.1186/s12935-021-02344-6
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AT dengjunlin ecadherinonepithelialmesenchymaltransitioninthyroidcancer

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