Smad3 deficiency improves islet-based therapy for diabetes and diabetic kidney injury by promoting β cell proliferation via the E2F3-dependent mechanism

Rationale: Poor β cell proliferation is one of the detrimental factors hindering islet cell replacement therapy for patients with diabetes. Smad3 is an important transcriptional factor of TGF-β signaling and has been shown to promote diabetes by inhibiting β cell proliferation. Therefore, we hypothe...

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Detalles Bibliográficos
Autores principales: Wang, Hong-Lian, Wei, Biao, He, Hui-Jun, Huang, Xiao-Ru, Sheng, Jing-Yi, Chen, Xiao-Cui, Wang, Li, Tan, Rui-Zhi, Li, Jian-Chun, Liu, Jian, Yang, Si-Jin, Ma, Ronald CW, Lan, Hui-Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690916/
https://www.ncbi.nlm.nih.gov/pubmed/34987651
http://dx.doi.org/10.7150/thno.67034

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