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Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs
Theranostics is an emerging paradigm that combines imaging and therapy in order to personalize patient treatment. In nuclear medicine, this is achieved by using radiopharmaceuticals that target identical molecular targets for both imaging (using emitted gamma rays) and radiopharmaceutical therapy (u...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690938/ https://www.ncbi.nlm.nih.gov/pubmed/34987643 http://dx.doi.org/10.7150/thno.62851 |
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author | Miller, Cassandra Rousseau, Julie Ramogida, Caterina F. Celler, Anna Rahmim, Arman Uribe, Carlos F. |
author_facet | Miller, Cassandra Rousseau, Julie Ramogida, Caterina F. Celler, Anna Rahmim, Arman Uribe, Carlos F. |
author_sort | Miller, Cassandra |
collection | PubMed |
description | Theranostics is an emerging paradigm that combines imaging and therapy in order to personalize patient treatment. In nuclear medicine, this is achieved by using radiopharmaceuticals that target identical molecular targets for both imaging (using emitted gamma rays) and radiopharmaceutical therapy (using emitted beta, alpha or Auger-electron particles) for the treatment of various diseases, such as cancer. If the therapeutic radiopharmaceutical cannot be imaged quantitatively, a “theranostic pair” imaging surrogate can be used to predict the absorbed radiation doses from the therapeutic radiopharmaceutical. However, theranostic dosimetry assumes that the pharmacokinetics and biodistributions of both radiopharmaceuticals in the pair are identical or very similar, an assumption that still requires further validation for many theranostic pairs. In this review, we consider both same-element and different-element theranostic pairs and attempt to determine if factors exist which may cause inaccurate dose extrapolations in theranostic dosimetry, either intrinsic (e.g. chemical differences) or extrinsic (e.g. injecting different amounts of each radiopharmaceutical) to the radiopharmaceuticals. We discuss the basis behind theranostic dosimetry and present common theranostic pairs and their therapeutic applications in oncology. We investigate general factors that could create alterations in the behavior of the radiopharmaceuticals or the quantitative accuracy of imaging them. Finally, we attempt to determine if there is evidence showing some specific pairs as suitable for theranostic dosimetry. We show that there are a variety of intrinsic and extrinsic factors which can significantly alter the behavior among pairs of radiopharmaceuticals, even if they belong to the same chemical element. More research is needed to determine the impact of these factors on theranostic dosimetry estimates and on patient outcomes, and how to correctly account for them. |
format | Online Article Text |
id | pubmed-8690938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-86909382022-01-04 Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs Miller, Cassandra Rousseau, Julie Ramogida, Caterina F. Celler, Anna Rahmim, Arman Uribe, Carlos F. Theranostics Review Theranostics is an emerging paradigm that combines imaging and therapy in order to personalize patient treatment. In nuclear medicine, this is achieved by using radiopharmaceuticals that target identical molecular targets for both imaging (using emitted gamma rays) and radiopharmaceutical therapy (using emitted beta, alpha or Auger-electron particles) for the treatment of various diseases, such as cancer. If the therapeutic radiopharmaceutical cannot be imaged quantitatively, a “theranostic pair” imaging surrogate can be used to predict the absorbed radiation doses from the therapeutic radiopharmaceutical. However, theranostic dosimetry assumes that the pharmacokinetics and biodistributions of both radiopharmaceuticals in the pair are identical or very similar, an assumption that still requires further validation for many theranostic pairs. In this review, we consider both same-element and different-element theranostic pairs and attempt to determine if factors exist which may cause inaccurate dose extrapolations in theranostic dosimetry, either intrinsic (e.g. chemical differences) or extrinsic (e.g. injecting different amounts of each radiopharmaceutical) to the radiopharmaceuticals. We discuss the basis behind theranostic dosimetry and present common theranostic pairs and their therapeutic applications in oncology. We investigate general factors that could create alterations in the behavior of the radiopharmaceuticals or the quantitative accuracy of imaging them. Finally, we attempt to determine if there is evidence showing some specific pairs as suitable for theranostic dosimetry. We show that there are a variety of intrinsic and extrinsic factors which can significantly alter the behavior among pairs of radiopharmaceuticals, even if they belong to the same chemical element. More research is needed to determine the impact of these factors on theranostic dosimetry estimates and on patient outcomes, and how to correctly account for them. Ivyspring International Publisher 2022-01-01 /pmc/articles/PMC8690938/ /pubmed/34987643 http://dx.doi.org/10.7150/thno.62851 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Miller, Cassandra Rousseau, Julie Ramogida, Caterina F. Celler, Anna Rahmim, Arman Uribe, Carlos F. Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs |
title | Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs |
title_full | Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs |
title_fullStr | Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs |
title_full_unstemmed | Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs |
title_short | Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs |
title_sort | implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690938/ https://www.ncbi.nlm.nih.gov/pubmed/34987643 http://dx.doi.org/10.7150/thno.62851 |
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