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Microfluidics for core–shell drug carrier particles – a review

Core–shell drug-carrier particles are known for their unique features. Due to the combination of superior properties not exhibited by the individual components, core–shell particles have gained a lot of interest. The structures could integrate core and shell characteristics and properties. These par...

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Autores principales: Yazdian Kashani, Sepideh, Afzalian, Amir, Shirinichi, Farbod, Keshavarz Moraveji, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691093/
https://www.ncbi.nlm.nih.gov/pubmed/35423057
http://dx.doi.org/10.1039/d0ra08607j
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author Yazdian Kashani, Sepideh
Afzalian, Amir
Shirinichi, Farbod
Keshavarz Moraveji, Mostafa
author_facet Yazdian Kashani, Sepideh
Afzalian, Amir
Shirinichi, Farbod
Keshavarz Moraveji, Mostafa
author_sort Yazdian Kashani, Sepideh
collection PubMed
description Core–shell drug-carrier particles are known for their unique features. Due to the combination of superior properties not exhibited by the individual components, core–shell particles have gained a lot of interest. The structures could integrate core and shell characteristics and properties. These particles were designed for controlled drug release in the desired location. Therefore, the side effects would be minimized. So, these particles' advantages have led to the introduction of new methods and ideas for their fabrication. In the past few years, the generation of drug carrier core–shell particles in microfluidic chips has attracted much attention. This method makes it possible to produce particles at nanometer and micrometer levels of the same shape and size; it usually costs less than other methods. The other advantages of using microfluidic techniques compared to conventional bulk methods are integration capability, reproducibility, and higher efficiency. These advantages have created a positive outlook on this approach. This review gives an overview of the various fluidic concepts that are used to generate microparticles or nanoparticles. Also, an overview of traditional and more recent microfluidic devices and their design and structure for the generation of core–shell particles is given. The unique benefits of the microfluidic technique for core–shell drug carrier particle generation are demonstrated.
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spelling pubmed-86910932022-04-13 Microfluidics for core–shell drug carrier particles – a review Yazdian Kashani, Sepideh Afzalian, Amir Shirinichi, Farbod Keshavarz Moraveji, Mostafa RSC Adv Chemistry Core–shell drug-carrier particles are known for their unique features. Due to the combination of superior properties not exhibited by the individual components, core–shell particles have gained a lot of interest. The structures could integrate core and shell characteristics and properties. These particles were designed for controlled drug release in the desired location. Therefore, the side effects would be minimized. So, these particles' advantages have led to the introduction of new methods and ideas for their fabrication. In the past few years, the generation of drug carrier core–shell particles in microfluidic chips has attracted much attention. This method makes it possible to produce particles at nanometer and micrometer levels of the same shape and size; it usually costs less than other methods. The other advantages of using microfluidic techniques compared to conventional bulk methods are integration capability, reproducibility, and higher efficiency. These advantages have created a positive outlook on this approach. This review gives an overview of the various fluidic concepts that are used to generate microparticles or nanoparticles. Also, an overview of traditional and more recent microfluidic devices and their design and structure for the generation of core–shell particles is given. The unique benefits of the microfluidic technique for core–shell drug carrier particle generation are demonstrated. The Royal Society of Chemistry 2020-12-23 /pmc/articles/PMC8691093/ /pubmed/35423057 http://dx.doi.org/10.1039/d0ra08607j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Yazdian Kashani, Sepideh
Afzalian, Amir
Shirinichi, Farbod
Keshavarz Moraveji, Mostafa
Microfluidics for core–shell drug carrier particles – a review
title Microfluidics for core–shell drug carrier particles – a review
title_full Microfluidics for core–shell drug carrier particles – a review
title_fullStr Microfluidics for core–shell drug carrier particles – a review
title_full_unstemmed Microfluidics for core–shell drug carrier particles – a review
title_short Microfluidics for core–shell drug carrier particles – a review
title_sort microfluidics for core–shell drug carrier particles – a review
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691093/
https://www.ncbi.nlm.nih.gov/pubmed/35423057
http://dx.doi.org/10.1039/d0ra08607j
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