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Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma

PURPOSE: To investigate the correlation between changes in lamina cribrosa (LC) structure using enhanced depth imaging (EDI) and severity of visual field (VF) affection in primary open-angle glaucoma (POAG). PATIENTS AND METHODS: This prospective cross-sectional study was carried out on 52 glaucomat...

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Autores principales: El Basty, Ahmed, Gaber, Raouf, Elmaria, Ahmed, Sabry, Moataz, Hussein, Tarek R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691195/
https://www.ncbi.nlm.nih.gov/pubmed/34949912
http://dx.doi.org/10.2147/OPTH.S343019
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author El Basty, Ahmed
Gaber, Raouf
Elmaria, Ahmed
Sabry, Moataz
Hussein, Tarek R
author_facet El Basty, Ahmed
Gaber, Raouf
Elmaria, Ahmed
Sabry, Moataz
Hussein, Tarek R
author_sort El Basty, Ahmed
collection PubMed
description PURPOSE: To investigate the correlation between changes in lamina cribrosa (LC) structure using enhanced depth imaging (EDI) and severity of visual field (VF) affection in primary open-angle glaucoma (POAG). PATIENTS AND METHODS: This prospective cross-sectional study was carried out on 52 glaucomatous eyes of 28 POAG patients who attended Tanta University Eye Hospital and 40 normal eyes of 20 age-matched normal subjects from April 2020 to March 2021. POAG patients were classified according to the modified Hodapp–Anderson–Parrish grading scale based on the MD of the standard automated perimetry (SAP) visual field into two groups: group (1) – mild-to-moderate POAG patients (MD ≤ 12 dB), group (2) – severe POAG patients (MD ≥ 12 dB) and the third group included normal (control) age- and gender-matched individuals. RESULTS: There was no statistically significant difference between the three groups regarding lamina cribrosa thickness nor lamina cribrosa area and there was no statistically significant correlation between MD and LC thickness, LC area (P-value=0.395 and 0.644). There was a statistically significant correlation between MD and anterior lamina cribrosa surface depth (P-value=0.002) and there was a statistically significant positive correlation between MD and prelaminar neural tissue (PLNT) thickness and prelaminar neural tissue (PLNT) area (P-value= 0.023 and <0.001, respectively). CONCLUSION: EDI-OCT is a useful biomarker of structural changes in ONH and LC, and we recommended it to be a part of the routine monitoring of patients with POAG.
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spelling pubmed-86911952021-12-22 Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma El Basty, Ahmed Gaber, Raouf Elmaria, Ahmed Sabry, Moataz Hussein, Tarek R Clin Ophthalmol Original Research PURPOSE: To investigate the correlation between changes in lamina cribrosa (LC) structure using enhanced depth imaging (EDI) and severity of visual field (VF) affection in primary open-angle glaucoma (POAG). PATIENTS AND METHODS: This prospective cross-sectional study was carried out on 52 glaucomatous eyes of 28 POAG patients who attended Tanta University Eye Hospital and 40 normal eyes of 20 age-matched normal subjects from April 2020 to March 2021. POAG patients were classified according to the modified Hodapp–Anderson–Parrish grading scale based on the MD of the standard automated perimetry (SAP) visual field into two groups: group (1) – mild-to-moderate POAG patients (MD ≤ 12 dB), group (2) – severe POAG patients (MD ≥ 12 dB) and the third group included normal (control) age- and gender-matched individuals. RESULTS: There was no statistically significant difference between the three groups regarding lamina cribrosa thickness nor lamina cribrosa area and there was no statistically significant correlation between MD and LC thickness, LC area (P-value=0.395 and 0.644). There was a statistically significant correlation between MD and anterior lamina cribrosa surface depth (P-value=0.002) and there was a statistically significant positive correlation between MD and prelaminar neural tissue (PLNT) thickness and prelaminar neural tissue (PLNT) area (P-value= 0.023 and <0.001, respectively). CONCLUSION: EDI-OCT is a useful biomarker of structural changes in ONH and LC, and we recommended it to be a part of the routine monitoring of patients with POAG. Dove 2021-12-17 /pmc/articles/PMC8691195/ /pubmed/34949912 http://dx.doi.org/10.2147/OPTH.S343019 Text en © 2021 El Basty et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
El Basty, Ahmed
Gaber, Raouf
Elmaria, Ahmed
Sabry, Moataz
Hussein, Tarek R
Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma
title Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma
title_full Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma
title_fullStr Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma
title_full_unstemmed Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma
title_short Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma
title_sort correlation between changes in lamina cribrosa structure and visual field in primary open-angle glaucoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691195/
https://www.ncbi.nlm.nih.gov/pubmed/34949912
http://dx.doi.org/10.2147/OPTH.S343019
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