Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform

We report a silicon microfluidic platform that enables monolithic integration of transparent micron-scale microfluidic channels, an on-chip segmentation of analyte flows into picoliter-volume droplets, and a nano-electrospray ionization emitter that enables spatial and temporal separation of oil and...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Kim, Sungho, Shi, Weihua, Zhao, Yaoyao, Park, Insu, Brenden, Christopher, Iyer, Hrishikesh, Jha, Prasoon, Bashir, Rashid, Sweedler, Jonathan V., Vlasov, Yurii
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691365/
https://www.ncbi.nlm.nih.gov/pubmed/34897344
http://dx.doi.org/10.1039/d1lc00758k
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author Zhang, Yan
Kim, Sungho
Shi, Weihua
Zhao, Yaoyao
Park, Insu
Brenden, Christopher
Iyer, Hrishikesh
Jha, Prasoon
Bashir, Rashid
Sweedler, Jonathan V.
Vlasov, Yurii
author_facet Zhang, Yan
Kim, Sungho
Shi, Weihua
Zhao, Yaoyao
Park, Insu
Brenden, Christopher
Iyer, Hrishikesh
Jha, Prasoon
Bashir, Rashid
Sweedler, Jonathan V.
Vlasov, Yurii
author_sort Zhang, Yan
collection PubMed
description We report a silicon microfluidic platform that enables monolithic integration of transparent micron-scale microfluidic channels, an on-chip segmentation of analyte flows into picoliter-volume droplets, and a nano-electrospray ionization emitter that enables spatial and temporal separation of oil and aqueous phases during electro-spray for subsequent mass spectrometry analysis.
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spelling pubmed-86913652022-01-11 Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform Zhang, Yan Kim, Sungho Shi, Weihua Zhao, Yaoyao Park, Insu Brenden, Christopher Iyer, Hrishikesh Jha, Prasoon Bashir, Rashid Sweedler, Jonathan V. Vlasov, Yurii Lab Chip Chemistry We report a silicon microfluidic platform that enables monolithic integration of transparent micron-scale microfluidic channels, an on-chip segmentation of analyte flows into picoliter-volume droplets, and a nano-electrospray ionization emitter that enables spatial and temporal separation of oil and aqueous phases during electro-spray for subsequent mass spectrometry analysis. The Royal Society of Chemistry 2021-12-12 /pmc/articles/PMC8691365/ /pubmed/34897344 http://dx.doi.org/10.1039/d1lc00758k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhang, Yan
Kim, Sungho
Shi, Weihua
Zhao, Yaoyao
Park, Insu
Brenden, Christopher
Iyer, Hrishikesh
Jha, Prasoon
Bashir, Rashid
Sweedler, Jonathan V.
Vlasov, Yurii
Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform
title Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform
title_full Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform
title_fullStr Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform
title_full_unstemmed Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform
title_short Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform
title_sort droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691365/
https://www.ncbi.nlm.nih.gov/pubmed/34897344
http://dx.doi.org/10.1039/d1lc00758k
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