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IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis

After the outburst of the SARS-CoV-2 pandemic, a worldwide research effort has led to the uncovering of many aspects of the COVID-19, among which we can count the outstanding role played by inflammatory cytokine milieu in the disease progression. Despite that, molecular mechanisms that regulate SARS...

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Autores principales: Cioccarelli, Chiara, Sánchez-Rodríguez, Ricardo, Angioni, Roberta, Venegas, Francisca C., Bertoldi, Nicole, Munari, Fabio, Cattelan, Annamaria, Molon, Barbara, Viola, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691651/
https://www.ncbi.nlm.nih.gov/pubmed/34950146
http://dx.doi.org/10.3389/fimmu.2021.781352
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author Cioccarelli, Chiara
Sánchez-Rodríguez, Ricardo
Angioni, Roberta
Venegas, Francisca C.
Bertoldi, Nicole
Munari, Fabio
Cattelan, Annamaria
Molon, Barbara
Viola, Antonella
author_facet Cioccarelli, Chiara
Sánchez-Rodríguez, Ricardo
Angioni, Roberta
Venegas, Francisca C.
Bertoldi, Nicole
Munari, Fabio
Cattelan, Annamaria
Molon, Barbara
Viola, Antonella
author_sort Cioccarelli, Chiara
collection PubMed
description After the outburst of the SARS-CoV-2 pandemic, a worldwide research effort has led to the uncovering of many aspects of the COVID-19, among which we can count the outstanding role played by inflammatory cytokine milieu in the disease progression. Despite that, molecular mechanisms that regulate SARS-CoV-2 pathogenesis are still almost unidentified. In this study, we investigated whether the pro-inflammatory milieu of the host affects the susceptibility of SARS-CoV-2 infection by modulating ACE2 and TMPRSS2 expression. Our results indicated that the host inflammatory milieu favors SARS-CoV-2 infection by directly increasing TMPRSS2 expression. We unveiled the molecular mechanism that regulates this process and that can be therapeutically advantageously targeted.
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spelling pubmed-86916512021-12-22 IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis Cioccarelli, Chiara Sánchez-Rodríguez, Ricardo Angioni, Roberta Venegas, Francisca C. Bertoldi, Nicole Munari, Fabio Cattelan, Annamaria Molon, Barbara Viola, Antonella Front Immunol Immunology After the outburst of the SARS-CoV-2 pandemic, a worldwide research effort has led to the uncovering of many aspects of the COVID-19, among which we can count the outstanding role played by inflammatory cytokine milieu in the disease progression. Despite that, molecular mechanisms that regulate SARS-CoV-2 pathogenesis are still almost unidentified. In this study, we investigated whether the pro-inflammatory milieu of the host affects the susceptibility of SARS-CoV-2 infection by modulating ACE2 and TMPRSS2 expression. Our results indicated that the host inflammatory milieu favors SARS-CoV-2 infection by directly increasing TMPRSS2 expression. We unveiled the molecular mechanism that regulates this process and that can be therapeutically advantageously targeted. Frontiers Media S.A. 2021-12-07 /pmc/articles/PMC8691651/ /pubmed/34950146 http://dx.doi.org/10.3389/fimmu.2021.781352 Text en Copyright © 2021 Cioccarelli, Sánchez-Rodríguez, Angioni, Venegas, Bertoldi, Munari, Cattelan, Molon and Viola https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cioccarelli, Chiara
Sánchez-Rodríguez, Ricardo
Angioni, Roberta
Venegas, Francisca C.
Bertoldi, Nicole
Munari, Fabio
Cattelan, Annamaria
Molon, Barbara
Viola, Antonella
IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis
title IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis
title_full IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis
title_fullStr IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis
title_full_unstemmed IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis
title_short IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis
title_sort il1β promotes tmprss2 expression and sars-cov-2 cell entry through the p38 mapk-gata2 axis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691651/
https://www.ncbi.nlm.nih.gov/pubmed/34950146
http://dx.doi.org/10.3389/fimmu.2021.781352
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