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IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis
After the outburst of the SARS-CoV-2 pandemic, a worldwide research effort has led to the uncovering of many aspects of the COVID-19, among which we can count the outstanding role played by inflammatory cytokine milieu in the disease progression. Despite that, molecular mechanisms that regulate SARS...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691651/ https://www.ncbi.nlm.nih.gov/pubmed/34950146 http://dx.doi.org/10.3389/fimmu.2021.781352 |
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author | Cioccarelli, Chiara Sánchez-Rodríguez, Ricardo Angioni, Roberta Venegas, Francisca C. Bertoldi, Nicole Munari, Fabio Cattelan, Annamaria Molon, Barbara Viola, Antonella |
author_facet | Cioccarelli, Chiara Sánchez-Rodríguez, Ricardo Angioni, Roberta Venegas, Francisca C. Bertoldi, Nicole Munari, Fabio Cattelan, Annamaria Molon, Barbara Viola, Antonella |
author_sort | Cioccarelli, Chiara |
collection | PubMed |
description | After the outburst of the SARS-CoV-2 pandemic, a worldwide research effort has led to the uncovering of many aspects of the COVID-19, among which we can count the outstanding role played by inflammatory cytokine milieu in the disease progression. Despite that, molecular mechanisms that regulate SARS-CoV-2 pathogenesis are still almost unidentified. In this study, we investigated whether the pro-inflammatory milieu of the host affects the susceptibility of SARS-CoV-2 infection by modulating ACE2 and TMPRSS2 expression. Our results indicated that the host inflammatory milieu favors SARS-CoV-2 infection by directly increasing TMPRSS2 expression. We unveiled the molecular mechanism that regulates this process and that can be therapeutically advantageously targeted. |
format | Online Article Text |
id | pubmed-8691651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86916512021-12-22 IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis Cioccarelli, Chiara Sánchez-Rodríguez, Ricardo Angioni, Roberta Venegas, Francisca C. Bertoldi, Nicole Munari, Fabio Cattelan, Annamaria Molon, Barbara Viola, Antonella Front Immunol Immunology After the outburst of the SARS-CoV-2 pandemic, a worldwide research effort has led to the uncovering of many aspects of the COVID-19, among which we can count the outstanding role played by inflammatory cytokine milieu in the disease progression. Despite that, molecular mechanisms that regulate SARS-CoV-2 pathogenesis are still almost unidentified. In this study, we investigated whether the pro-inflammatory milieu of the host affects the susceptibility of SARS-CoV-2 infection by modulating ACE2 and TMPRSS2 expression. Our results indicated that the host inflammatory milieu favors SARS-CoV-2 infection by directly increasing TMPRSS2 expression. We unveiled the molecular mechanism that regulates this process and that can be therapeutically advantageously targeted. Frontiers Media S.A. 2021-12-07 /pmc/articles/PMC8691651/ /pubmed/34950146 http://dx.doi.org/10.3389/fimmu.2021.781352 Text en Copyright © 2021 Cioccarelli, Sánchez-Rodríguez, Angioni, Venegas, Bertoldi, Munari, Cattelan, Molon and Viola https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Cioccarelli, Chiara Sánchez-Rodríguez, Ricardo Angioni, Roberta Venegas, Francisca C. Bertoldi, Nicole Munari, Fabio Cattelan, Annamaria Molon, Barbara Viola, Antonella IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis |
title | IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis |
title_full | IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis |
title_fullStr | IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis |
title_full_unstemmed | IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis |
title_short | IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis |
title_sort | il1β promotes tmprss2 expression and sars-cov-2 cell entry through the p38 mapk-gata2 axis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691651/ https://www.ncbi.nlm.nih.gov/pubmed/34950146 http://dx.doi.org/10.3389/fimmu.2021.781352 |
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