Cargando…

IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis

After the outburst of the SARS-CoV-2 pandemic, a worldwide research effort has led to the uncovering of many aspects of the COVID-19, among which we can count the outstanding role played by inflammatory cytokine milieu in the disease progression. Despite that, molecular mechanisms that regulate SARS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cioccarelli, Chiara, Sánchez-Rodríguez, Ricardo, Angioni, Roberta, Venegas, Francisca C., Bertoldi, Nicole, Munari, Fabio, Cattelan, Annamaria, Molon, Barbara, Viola, Antonella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691651/ https://www.ncbi.nlm.nih.gov/pubmed/34950146 http://dx.doi.org/10.3389/fimmu.2021.781352

Ejemplares similares

COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients
por: Angioni, Roberta, et al.
Publicado: (2022)

Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients
por: Angioni, Roberta, et al.
Publicado: (2020)

OPA1 drives macrophage metabolism and functional commitment via p65 signaling
por: Sánchez-Rodríguez, Ricardo, et al.
Publicado: (2022)

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2
por: Ou, Tianling, et al.
Publicado: (2021)

Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2
por: Qiao, Yuanyuan, et al.
Publicado: (2021)

Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis
por: Zumerle, Sara, et al.
Publicado: (2019)

Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory Tract
por: Liu, Yichuan, et al.
Publicado: (2020)

Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD
por: Burgueño, Juan F, et al.
Publicado: (2020)

Tmprss2 specific miRNAs as promising regulators for SARS-CoV-2 entry checkpoint
por: Kaur, Taruneet, et al.
Publicado: (2021)

Antiandrogens Target TMPRSS2 and Reduce SARS-CoV-2 Virus Entry in Lung Cells
por: Leach, Damien A, et al.
Publicado: (2021)

NSP16 promotes the expression of TMPRSS2 to enhance SARS-CoV-2 cell entry
por: Han, Tianyu, et al.
Publicado: (2022)

Co-expression of the SARS-CoV-2 entry receptors ACE2 and TMPRSS2 in healthy human conjunctiva
por: Mencucci, Rita, et al.
Publicado: (2021)

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells
por: Koch, Jana, et al.
Publicado: (2021)

Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat
por: Hempel, Tim, et al.
Publicado: (2020)

Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges
por: Mahmoud, Ismail Sami, et al.
Publicado: (2021)

Exploring the phytochemicals of Platycodon grandiflorus for TMPRSS2 inhibition in the search for SARS-CoV-2 entry inhibitors
por: Gurung, Arun Bahadur, et al.
Publicado: (2022)

Variability in genes related to SARS-CoV-2 entry into host cells (ACE2, TMPRSS2, TMPRSS11A, ELANE, and CTSL) and its potential use in association studies
por: Vargas-Alarcón, Gilberto, et al.
Publicado: (2020)

Junin Virus Activates p38 MAPK and HSP27 Upon Entry
por: Fitzpatrick, Collin J., et al.
Publicado: (2022)

SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study
por: Baby, Krishnaprasad, et al.
Publicado: (2021)

Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin
por: Ouyang, Yingshi, et al.
Publicado: (2021)

The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
por: Leach, D. A., et al.
Publicado: (2021)

SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity
por: Meng, Bo, et al.
Publicado: (2022)

Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells
por: Icho, Simoun, et al.
Publicado: (2022)

Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry
por: Shirato, Kazuya, et al.
Publicado: (2018)

Role of GATA transcription factor ELT-2 and p38 MAPK PMK-1 in recovery from acute P. aeruginosa infection in C. elegans
por: Head, Brian P., et al.
Publicado: (2016)

SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal–Fetal Interface
por: Chen, Wei, et al.
Publicado: (2020)

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
por: Hoffmann, Markus, et al.
Publicado: (2020)

GATA2 deficiency phenotype associated with tandem duplication of GATA2 and overexpression of GATA2-AS1
por: Singh, Preeti, et al.
Publicado: (2021)

Homology modeling of TMPRSS2 yields candidate drugs that may inhibit entry of SARS-CoV-2 into human cells.
por: Rensi, Stefano, et al.
Publicado: (2020)

Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L
por: Prasad, Kartikay, et al.
Publicado: (2021)

BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry
por: Moumbock, Aurélien F. A., et al.
Publicado: (2022)

MBD2 Mediates Septic AKI through Activation of PKCη/p38MAPK and the ERK1/2 Axis
por: Xie, Yuxin, et al.
Publicado: (2020)

The p38(MAPK)-MK2 Signaling Axis as a Critical Link Between Inflammation and Synaptic Transmission
por: Beamer, Edward, et al.
Publicado: (2021)

Commentary: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
por: Djomkam, Alexandra Lindsey Zune, et al.
Publicado: (2020)

Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury
por: Bengs, Susan, et al.
Publicado: (2021)

RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity
por: Angioni, Roberta, et al.
Publicado: (2023)

Autophagy in inflammation: the p38α MAPK-ULK1 axis
por: She, Hua, et al.
Publicado: (2018)

TGF-β in Cancer: Metabolic Driver of the Tolerogenic Crosstalk in the Tumor Microenvironment
por: Angioni, Roberta, et al.
Publicado: (2021)

Structural modeling and analysis of the SARS-CoV-2 cell entry inhibitor camostat bound to the trypsin-like protease TMPRSS2
por: Escalante, Diego E., et al.
Publicado: (2021)

Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes
por: Robinson, Emma L., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3phlmcgiq2i6uvqp6l7o991fu9