Cargando…

Effects of canagliflozin on human myocardial redox signalling: clinical implications

AIMS: Recent clinical trials indicate that sodium-glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular outcomes in heart failure patients, but the underlying mechanisms remain unknown. We explored the direct effects of canagliflozin, an SGLT2 inhibitor with mild SGLT1 inhibitory effects...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kondo, Hidekazu, Akoumianakis, Ioannis, Badi, Ileana, Akawi, Nadia, Kotanidis, Christos P, Polkinghorne, Murray, Stadiotti, Ilaria, Sommariva, Elena, Antonopoulos, Alexios S, Carena, Maria C, Oikonomou, Evangelos K, Reus, Elsa Mauricio, Sayeed, Rana, Krasopoulos, George, Srivastava, Vivek, Farid, Shakil, Chuaiphichai, Surawee, Shirodaria, Cheerag, Channon, Keith M, Casadei, Barbara, Antoniades, Charalambos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691807/ https://www.ncbi.nlm.nih.gov/pubmed/34293101 http://dx.doi.org/10.1093/eurheartj/ehab420

Ejemplares similares

Role of Human Epicardial Adipose Tissue–Derived miR-92a-3p in Myocardial Redox State
por: Carena, Maria Cristina, et al.
Publicado: (2023)

Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease
por: Akawi, Nadia, et al.
Publicado: (2021)

Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress
por: Margaritis, Marios, et al.
Publicado: (2017)

PHACTR1 modulates vascular compliance but not endothelial function: a translational study
por: Wood, Alice, et al.
Publicado: (2022)

Exploring the Crosstalk between Adipose Tissue and the Cardiovascular System
por: Akoumianakis, Ioannis, et al.
Publicado: (2017)

Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data
por: Oikonomou, Evangelos K, et al.
Publicado: (2018)

Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling
por: Antonopoulos, Alexios S., et al.
Publicado: (2016)

Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications
por: Akoumianakis, Ioannis, et al.
Publicado: (2022)

A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction
por: Douglas, Gillian, et al.
Publicado: (2020)

A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography
por: Oikonomou, Evangelos K, et al.
Publicado: (2019)

Editorial: Exploring the Crosstalk Between Adipose Tissue and the Cardiovascular System
por: Badi, Ileana, et al.
Publicado: (2022)

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension()
por: Chuaiphichai, Surawee, et al.
Publicado: (2016)

Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II–mediated blood pressure control
por: Patel, Jyoti, et al.
Publicado: (2018)

Statins as Anti-Inflammatory Agents in Atherogenesis: Molecular Mechanisms and Lessons from the Recent Clinical Trials
por: Antonopoulos, Alexios S, et al.
Publicado: (2012)

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19
por: Kotanidis, Christos P, et al.
Publicado: (2022)

A key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice
por: Chuaiphichai, Surawee, et al.
Publicado: (2017)

A Bleeding Kiss: intramural haematoma secondary to balloon angioplasty
por: Shirodaria, Cheerag, et al.
Publicado: (2007)

Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury
por: Chuaiphichai, Surawee, et al.
Publicado: (2023)

Development of a risk score for early saphenous vein graft failure: An individual patient data meta-analysis
por: Antonopoulos, Alexios S., et al.
Publicado: (2020)

Perivascular fat imaging by computed tomography (CT): a virtual guide
por: Kotanidis, Christos P., et al.
Publicado: (2021)

A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS): EFFECTS ON TETRAHYDROBIOPTERIN-DEPENDENT CATALYSIS AND eNOS DIMERIZATION
por: Benson, Matthew A., et al.
Publicado: (2013)

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II–Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm
por: Chuaiphichai, Surawee, et al.
Publicado: (2018)

Multimodal cardiovascular magnetic resonance quantifies regional variation in vascular structure and function in patients with coronary artery disease: Relationships with coronary disease severity
por: Kylintireas, Ilias, et al.
Publicado: (2011)

Graft flow assessment and early coronary artery bypass graft failure: a computed tomography analysis
por: D’Alessio, Andrea, et al.
Publicado: (2021)

Deep-Learning for Epicardial Adipose Tissue Assessment With Computed Tomography: Implications for Cardiovascular Risk Prediction
por: West, Henry W., et al.
Publicado: (2023)

Very low calorie diets are associated with transient ventricular impairment before reversal of diastolic dysfunction in obesity
por: Rayner, Jennifer J., et al.
Publicado: (2018)

Inflammatory Mechanisms in COVID-19 and Atherosclerosis: Current Pharmaceutical Perspectives
por: Sagris, Marios, et al.
Publicado: (2021)

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation
por: McNeill, Eileen, et al.
Publicado: (2015)

Crucial Role for Neuronal Nitric Oxide Synthase in Early Microcirculatory Derangement and Recipient Survival following Murine Pancreas Transplantation
por: Cardini, Benno, et al.
Publicado: (2014)

Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology
por: Bailey, Jade D., et al.
Publicado: (2020)

State-of-the-art review article. Atherosclerosis affecting fat: What can we learn by imaging perivascular adipose tissue?
por: Antoniades, Charalambos, et al.
Publicado: (2019)

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
por: Douglas, Gillian, et al.
Publicado: (2018)

The role of peri-aortic fat in aortic atherosclerosis
por: Kylintireas, Ilias, et al.
Publicado: (2009)

Human Cell Modeling for Cardiovascular Diseases
por: Lippi, Melania, et al.
Publicado: (2020)

Early changes in arterial structure and function following statin initiation: Quantification by magnetic resonance imaging
por: Lee, Justin M.S., et al.
Publicado: (2008)

Canagliflozin – Beginning of the journey
por: Pandey, Sunil Kumar, et al.
Publicado: (2014)

Cell models of arrhythmogenic cardiomyopathy: advances and opportunities
por: Sommariva, Elena, et al.
Publicado: (2017)

Inflammatory Mediators of Platelet Activation: Focus on Atherosclerosis and COVID-19
por: Theofilis, Panagiotis, et al.
Publicado: (2021)

Genetic Predisposition and Inflammatory Inhibitors in COVID-19: Where Do We Stand?
por: Sagris, Marios, et al.
Publicado: (2022)

Factors Associated with Platelet Activation-Recent Pharmaceutical Approaches
por: Theofilis, Panagiotis, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_d6v7la07ve6v57ibcjh65vs10k