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Cortico-subcortical β burst dynamics underlying movement cancellation in humans
Dominant neuroanatomical models hold that humans regulate their movements via loop-like cortico-subcortical networks, which include the subthalamic nucleus (STN), motor thalamus, and sensorimotor cortex (SMC). Inhibitory commands across these networks are purportedly sent via transient, burst-like s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691838/ https://www.ncbi.nlm.nih.gov/pubmed/34874267 http://dx.doi.org/10.7554/eLife.70270 |
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author | Diesburg, Darcy A Greenlee, Jeremy DW Wessel, Jan R |
author_facet | Diesburg, Darcy A Greenlee, Jeremy DW Wessel, Jan R |
author_sort | Diesburg, Darcy A |
collection | PubMed |
description | Dominant neuroanatomical models hold that humans regulate their movements via loop-like cortico-subcortical networks, which include the subthalamic nucleus (STN), motor thalamus, and sensorimotor cortex (SMC). Inhibitory commands across these networks are purportedly sent via transient, burst-like signals in the β frequency (15–29 Hz). However, since human depth-recording studies are typically limited to one recording site, direct evidence for this proposition is hitherto lacking. Here, we present simultaneous multi-site recordings from SMC and either STN or motor thalamus in humans performing the stop-signal task. In line with their purported function as inhibitory signals, subcortical β-bursts were increased on successful stop-trials. STN bursts in particular were followed within 50 ms by increased β-bursting over SMC. Moreover, between-site comparisons (including in a patient with simultaneous recordings from SMC, thalamus, and STN) confirmed that β-bursts in STN temporally precede thalamic β-bursts. This highly unique set of recordings provides empirical evidence for the role of β-bursts in conveying inhibitory commands along long-proposed cortico-subcortical networks underlying movement regulation in humans. |
format | Online Article Text |
id | pubmed-8691838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-86918382021-12-22 Cortico-subcortical β burst dynamics underlying movement cancellation in humans Diesburg, Darcy A Greenlee, Jeremy DW Wessel, Jan R eLife Neuroscience Dominant neuroanatomical models hold that humans regulate their movements via loop-like cortico-subcortical networks, which include the subthalamic nucleus (STN), motor thalamus, and sensorimotor cortex (SMC). Inhibitory commands across these networks are purportedly sent via transient, burst-like signals in the β frequency (15–29 Hz). However, since human depth-recording studies are typically limited to one recording site, direct evidence for this proposition is hitherto lacking. Here, we present simultaneous multi-site recordings from SMC and either STN or motor thalamus in humans performing the stop-signal task. In line with their purported function as inhibitory signals, subcortical β-bursts were increased on successful stop-trials. STN bursts in particular were followed within 50 ms by increased β-bursting over SMC. Moreover, between-site comparisons (including in a patient with simultaneous recordings from SMC, thalamus, and STN) confirmed that β-bursts in STN temporally precede thalamic β-bursts. This highly unique set of recordings provides empirical evidence for the role of β-bursts in conveying inhibitory commands along long-proposed cortico-subcortical networks underlying movement regulation in humans. eLife Sciences Publications, Ltd 2021-12-07 /pmc/articles/PMC8691838/ /pubmed/34874267 http://dx.doi.org/10.7554/eLife.70270 Text en © 2021, Diesburg et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Diesburg, Darcy A Greenlee, Jeremy DW Wessel, Jan R Cortico-subcortical β burst dynamics underlying movement cancellation in humans |
title | Cortico-subcortical β burst dynamics underlying movement cancellation in humans |
title_full | Cortico-subcortical β burst dynamics underlying movement cancellation in humans |
title_fullStr | Cortico-subcortical β burst dynamics underlying movement cancellation in humans |
title_full_unstemmed | Cortico-subcortical β burst dynamics underlying movement cancellation in humans |
title_short | Cortico-subcortical β burst dynamics underlying movement cancellation in humans |
title_sort | cortico-subcortical β burst dynamics underlying movement cancellation in humans |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691838/ https://www.ncbi.nlm.nih.gov/pubmed/34874267 http://dx.doi.org/10.7554/eLife.70270 |
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