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Cortico-subcortical β burst dynamics underlying movement cancellation in humans

Dominant neuroanatomical models hold that humans regulate their movements via loop-like cortico-subcortical networks, which include the subthalamic nucleus (STN), motor thalamus, and sensorimotor cortex (SMC). Inhibitory commands across these networks are purportedly sent via transient, burst-like s...

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Autores principales: Diesburg, Darcy A, Greenlee, Jeremy DW, Wessel, Jan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691838/
https://www.ncbi.nlm.nih.gov/pubmed/34874267
http://dx.doi.org/10.7554/eLife.70270
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author Diesburg, Darcy A
Greenlee, Jeremy DW
Wessel, Jan R
author_facet Diesburg, Darcy A
Greenlee, Jeremy DW
Wessel, Jan R
author_sort Diesburg, Darcy A
collection PubMed
description Dominant neuroanatomical models hold that humans regulate their movements via loop-like cortico-subcortical networks, which include the subthalamic nucleus (STN), motor thalamus, and sensorimotor cortex (SMC). Inhibitory commands across these networks are purportedly sent via transient, burst-like signals in the β frequency (15–29 Hz). However, since human depth-recording studies are typically limited to one recording site, direct evidence for this proposition is hitherto lacking. Here, we present simultaneous multi-site recordings from SMC and either STN or motor thalamus in humans performing the stop-signal task. In line with their purported function as inhibitory signals, subcortical β-bursts were increased on successful stop-trials. STN bursts in particular were followed within 50 ms by increased β-bursting over SMC. Moreover, between-site comparisons (including in a patient with simultaneous recordings from SMC, thalamus, and STN) confirmed that β-bursts in STN temporally precede thalamic β-bursts. This highly unique set of recordings provides empirical evidence for the role of β-bursts in conveying inhibitory commands along long-proposed cortico-subcortical networks underlying movement regulation in humans.
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spelling pubmed-86918382021-12-22 Cortico-subcortical β burst dynamics underlying movement cancellation in humans Diesburg, Darcy A Greenlee, Jeremy DW Wessel, Jan R eLife Neuroscience Dominant neuroanatomical models hold that humans regulate their movements via loop-like cortico-subcortical networks, which include the subthalamic nucleus (STN), motor thalamus, and sensorimotor cortex (SMC). Inhibitory commands across these networks are purportedly sent via transient, burst-like signals in the β frequency (15–29 Hz). However, since human depth-recording studies are typically limited to one recording site, direct evidence for this proposition is hitherto lacking. Here, we present simultaneous multi-site recordings from SMC and either STN or motor thalamus in humans performing the stop-signal task. In line with their purported function as inhibitory signals, subcortical β-bursts were increased on successful stop-trials. STN bursts in particular were followed within 50 ms by increased β-bursting over SMC. Moreover, between-site comparisons (including in a patient with simultaneous recordings from SMC, thalamus, and STN) confirmed that β-bursts in STN temporally precede thalamic β-bursts. This highly unique set of recordings provides empirical evidence for the role of β-bursts in conveying inhibitory commands along long-proposed cortico-subcortical networks underlying movement regulation in humans. eLife Sciences Publications, Ltd 2021-12-07 /pmc/articles/PMC8691838/ /pubmed/34874267 http://dx.doi.org/10.7554/eLife.70270 Text en © 2021, Diesburg et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Diesburg, Darcy A
Greenlee, Jeremy DW
Wessel, Jan R
Cortico-subcortical β burst dynamics underlying movement cancellation in humans
title Cortico-subcortical β burst dynamics underlying movement cancellation in humans
title_full Cortico-subcortical β burst dynamics underlying movement cancellation in humans
title_fullStr Cortico-subcortical β burst dynamics underlying movement cancellation in humans
title_full_unstemmed Cortico-subcortical β burst dynamics underlying movement cancellation in humans
title_short Cortico-subcortical β burst dynamics underlying movement cancellation in humans
title_sort cortico-subcortical β burst dynamics underlying movement cancellation in humans
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691838/
https://www.ncbi.nlm.nih.gov/pubmed/34874267
http://dx.doi.org/10.7554/eLife.70270
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