Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway

Simultaneous P53 loss and activation of the PTEN-restricted PI3K-AKT pathway frequently occur in aggressive breast cancers. P53 loss causes genome instability, while PTEN loss and/or activating mutations of PIK3CA and AKT promote cancer cell proliferation that also increases incidences of genomic ab...

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Detalles Bibliográficos
Autores principales: Martinez, Jarrod D., Mo, Qianxing, Xu, Yixiang, Qin, Li, Li, Yi, Xu, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692138/
https://www.ncbi.nlm.nih.gov/pubmed/34975329
http://dx.doi.org/10.7150/ijbs.65763

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