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Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome

BACKGROUND: The term big kidney‐little kidney syndrome in cats has been used for many years, but the definitions are not consistent and relevant research is limited. OBJECTIVE: To determine the factors that differ between normal and BKLK cats, as well as to develop models for predicting the 30‐day s...

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Autores principales: Wu, Yen‐Tse, Hung, Wan‐Chu, Huang, Po‐Yao, Tsai, Han‐Ju, Wu, Ching‐Ho, Lee, Ya‐Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692197/
https://www.ncbi.nlm.nih.gov/pubmed/34655128
http://dx.doi.org/10.1111/jvim.16279
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author Wu, Yen‐Tse
Hung, Wan‐Chu
Huang, Po‐Yao
Tsai, Han‐Ju
Wu, Ching‐Ho
Lee, Ya‐Jane
author_facet Wu, Yen‐Tse
Hung, Wan‐Chu
Huang, Po‐Yao
Tsai, Han‐Ju
Wu, Ching‐Ho
Lee, Ya‐Jane
author_sort Wu, Yen‐Tse
collection PubMed
description BACKGROUND: The term big kidney‐little kidney syndrome in cats has been used for many years, but the definitions are not consistent and relevant research is limited. OBJECTIVE: To determine the factors that differ between normal and BKLK cats, as well as to develop models for predicting the 30‐day survival of cats with ureteral obstruction (UO). ANIMALS: Sixteen healthy cats and 64 cats with BKLK. METHODS: Retrospective study. To define BKLK by reference to data from clinically healthy cats. The demographic and clinicopathological data among groups were statistically analyzed. RESULTS: Big kidney‐little kidney syndrome cats had higher blood urea nitrogen (BUN) (median [interquartile range] 69 [28‐162] vs 21 [19–24] mg/dL, P < .001), creatinine (5.6 [1.9‐13.3] vs 1.3 [1.05‐1.40] mg/dL, P < .001), and white blood cells (10 800 [7700‐17 500] vs 6500 [4875‐9350] /μL, P < .001) and lower hematocrit (32.8 [27.1‐38.4] vs 39.1 [38.1‐40.4]%, P < .001), urine specific gravity (1.011 [1.009‐1.016] vs 1.049 [1.044‐1.057], P < .001) and pH (5.88 [5.49‐6.44] vs 6.68 [6.00‐7.18], P = .001) compared to the control cats. A lower body temperature (BT; 38.1 [37.9‐38.2] vs 38.7 [38.3‐39.2]°C, P = .009), higher BUN (189 [150‐252] vs 91 [36‐170] mg/dL, P = .04), and creatinine (15.4 [13.3‐17.4] vs 9.0 [3.1‐14.2] mg/dL, P = .03) were found among the UO cats that were not 30‐day survivors. A combination of BUN, phosphorus, and BT can predict 30‐day survival among UO cats with an area under receiver operating characteristic curve of 0.863. (P = .01). CONCLUSION: An increase in the length difference between kidneys can indicate UO, but cannot predict outcome for BKLK cats.
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spelling pubmed-86921972022-01-03 Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome Wu, Yen‐Tse Hung, Wan‐Chu Huang, Po‐Yao Tsai, Han‐Ju Wu, Ching‐Ho Lee, Ya‐Jane J Vet Intern Med SMALL ANIMAL BACKGROUND: The term big kidney‐little kidney syndrome in cats has been used for many years, but the definitions are not consistent and relevant research is limited. OBJECTIVE: To determine the factors that differ between normal and BKLK cats, as well as to develop models for predicting the 30‐day survival of cats with ureteral obstruction (UO). ANIMALS: Sixteen healthy cats and 64 cats with BKLK. METHODS: Retrospective study. To define BKLK by reference to data from clinically healthy cats. The demographic and clinicopathological data among groups were statistically analyzed. RESULTS: Big kidney‐little kidney syndrome cats had higher blood urea nitrogen (BUN) (median [interquartile range] 69 [28‐162] vs 21 [19–24] mg/dL, P < .001), creatinine (5.6 [1.9‐13.3] vs 1.3 [1.05‐1.40] mg/dL, P < .001), and white blood cells (10 800 [7700‐17 500] vs 6500 [4875‐9350] /μL, P < .001) and lower hematocrit (32.8 [27.1‐38.4] vs 39.1 [38.1‐40.4]%, P < .001), urine specific gravity (1.011 [1.009‐1.016] vs 1.049 [1.044‐1.057], P < .001) and pH (5.88 [5.49‐6.44] vs 6.68 [6.00‐7.18], P = .001) compared to the control cats. A lower body temperature (BT; 38.1 [37.9‐38.2] vs 38.7 [38.3‐39.2]°C, P = .009), higher BUN (189 [150‐252] vs 91 [36‐170] mg/dL, P = .04), and creatinine (15.4 [13.3‐17.4] vs 9.0 [3.1‐14.2] mg/dL, P = .03) were found among the UO cats that were not 30‐day survivors. A combination of BUN, phosphorus, and BT can predict 30‐day survival among UO cats with an area under receiver operating characteristic curve of 0.863. (P = .01). CONCLUSION: An increase in the length difference between kidneys can indicate UO, but cannot predict outcome for BKLK cats. John Wiley & Sons, Inc. 2021-10-15 2021 /pmc/articles/PMC8692197/ /pubmed/34655128 http://dx.doi.org/10.1111/jvim.16279 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle SMALL ANIMAL
Wu, Yen‐Tse
Hung, Wan‐Chu
Huang, Po‐Yao
Tsai, Han‐Ju
Wu, Ching‐Ho
Lee, Ya‐Jane
Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome
title Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome
title_full Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome
title_fullStr Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome
title_full_unstemmed Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome
title_short Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome
title_sort evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692197/
https://www.ncbi.nlm.nih.gov/pubmed/34655128
http://dx.doi.org/10.1111/jvim.16279
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