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Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome
BACKGROUND: The term big kidney‐little kidney syndrome in cats has been used for many years, but the definitions are not consistent and relevant research is limited. OBJECTIVE: To determine the factors that differ between normal and BKLK cats, as well as to develop models for predicting the 30‐day s...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692197/ https://www.ncbi.nlm.nih.gov/pubmed/34655128 http://dx.doi.org/10.1111/jvim.16279 |
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author | Wu, Yen‐Tse Hung, Wan‐Chu Huang, Po‐Yao Tsai, Han‐Ju Wu, Ching‐Ho Lee, Ya‐Jane |
author_facet | Wu, Yen‐Tse Hung, Wan‐Chu Huang, Po‐Yao Tsai, Han‐Ju Wu, Ching‐Ho Lee, Ya‐Jane |
author_sort | Wu, Yen‐Tse |
collection | PubMed |
description | BACKGROUND: The term big kidney‐little kidney syndrome in cats has been used for many years, but the definitions are not consistent and relevant research is limited. OBJECTIVE: To determine the factors that differ between normal and BKLK cats, as well as to develop models for predicting the 30‐day survival of cats with ureteral obstruction (UO). ANIMALS: Sixteen healthy cats and 64 cats with BKLK. METHODS: Retrospective study. To define BKLK by reference to data from clinically healthy cats. The demographic and clinicopathological data among groups were statistically analyzed. RESULTS: Big kidney‐little kidney syndrome cats had higher blood urea nitrogen (BUN) (median [interquartile range] 69 [28‐162] vs 21 [19–24] mg/dL, P < .001), creatinine (5.6 [1.9‐13.3] vs 1.3 [1.05‐1.40] mg/dL, P < .001), and white blood cells (10 800 [7700‐17 500] vs 6500 [4875‐9350] /μL, P < .001) and lower hematocrit (32.8 [27.1‐38.4] vs 39.1 [38.1‐40.4]%, P < .001), urine specific gravity (1.011 [1.009‐1.016] vs 1.049 [1.044‐1.057], P < .001) and pH (5.88 [5.49‐6.44] vs 6.68 [6.00‐7.18], P = .001) compared to the control cats. A lower body temperature (BT; 38.1 [37.9‐38.2] vs 38.7 [38.3‐39.2]°C, P = .009), higher BUN (189 [150‐252] vs 91 [36‐170] mg/dL, P = .04), and creatinine (15.4 [13.3‐17.4] vs 9.0 [3.1‐14.2] mg/dL, P = .03) were found among the UO cats that were not 30‐day survivors. A combination of BUN, phosphorus, and BT can predict 30‐day survival among UO cats with an area under receiver operating characteristic curve of 0.863. (P = .01). CONCLUSION: An increase in the length difference between kidneys can indicate UO, but cannot predict outcome for BKLK cats. |
format | Online Article Text |
id | pubmed-8692197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86921972022-01-03 Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome Wu, Yen‐Tse Hung, Wan‐Chu Huang, Po‐Yao Tsai, Han‐Ju Wu, Ching‐Ho Lee, Ya‐Jane J Vet Intern Med SMALL ANIMAL BACKGROUND: The term big kidney‐little kidney syndrome in cats has been used for many years, but the definitions are not consistent and relevant research is limited. OBJECTIVE: To determine the factors that differ between normal and BKLK cats, as well as to develop models for predicting the 30‐day survival of cats with ureteral obstruction (UO). ANIMALS: Sixteen healthy cats and 64 cats with BKLK. METHODS: Retrospective study. To define BKLK by reference to data from clinically healthy cats. The demographic and clinicopathological data among groups were statistically analyzed. RESULTS: Big kidney‐little kidney syndrome cats had higher blood urea nitrogen (BUN) (median [interquartile range] 69 [28‐162] vs 21 [19–24] mg/dL, P < .001), creatinine (5.6 [1.9‐13.3] vs 1.3 [1.05‐1.40] mg/dL, P < .001), and white blood cells (10 800 [7700‐17 500] vs 6500 [4875‐9350] /μL, P < .001) and lower hematocrit (32.8 [27.1‐38.4] vs 39.1 [38.1‐40.4]%, P < .001), urine specific gravity (1.011 [1.009‐1.016] vs 1.049 [1.044‐1.057], P < .001) and pH (5.88 [5.49‐6.44] vs 6.68 [6.00‐7.18], P = .001) compared to the control cats. A lower body temperature (BT; 38.1 [37.9‐38.2] vs 38.7 [38.3‐39.2]°C, P = .009), higher BUN (189 [150‐252] vs 91 [36‐170] mg/dL, P = .04), and creatinine (15.4 [13.3‐17.4] vs 9.0 [3.1‐14.2] mg/dL, P = .03) were found among the UO cats that were not 30‐day survivors. A combination of BUN, phosphorus, and BT can predict 30‐day survival among UO cats with an area under receiver operating characteristic curve of 0.863. (P = .01). CONCLUSION: An increase in the length difference between kidneys can indicate UO, but cannot predict outcome for BKLK cats. John Wiley & Sons, Inc. 2021-10-15 2021 /pmc/articles/PMC8692197/ /pubmed/34655128 http://dx.doi.org/10.1111/jvim.16279 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | SMALL ANIMAL Wu, Yen‐Tse Hung, Wan‐Chu Huang, Po‐Yao Tsai, Han‐Ju Wu, Ching‐Ho Lee, Ya‐Jane Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome |
title | Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome |
title_full | Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome |
title_fullStr | Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome |
title_full_unstemmed | Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome |
title_short | Evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome |
title_sort | evaluation of and the prognostic factors for cats with big kidney‐little kidney syndrome |
topic | SMALL ANIMAL |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692197/ https://www.ncbi.nlm.nih.gov/pubmed/34655128 http://dx.doi.org/10.1111/jvim.16279 |
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