Cargando…

Choledochal stenting for treatment of extrahepatic biliary obstruction in cats

BACKGROUND: Limited information currently exists regarding the clinical progression and outcomes of cats that undergo choledochal stenting as a treatment for extrahepatic biliary obstruction (EHBO). HYPOTHESIS/OBJECTIVES: Describe clinical characteristics, indications for choledochal stent placement...

Descripción completa

Detalles Bibliográficos
Autores principales: Griffin, Maureen A., Culp, William T. N., Giuffrida, Michelle A., Selmic, Laura E., Denitz, Jordan C., Perry, James A., Schoelkopf, Alexander C., Milovancev, Milan, Phillips, Heidi, Wallace, Mandy L., Steffey, Michele A., Balsa, Ingrid M., Mayhew, Philipp D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692206/
https://www.ncbi.nlm.nih.gov/pubmed/34586683
http://dx.doi.org/10.1111/jvim.16176
_version_ 1784618909983309824
author Griffin, Maureen A.
Culp, William T. N.
Giuffrida, Michelle A.
Selmic, Laura E.
Denitz, Jordan C.
Perry, James A.
Schoelkopf, Alexander C.
Milovancev, Milan
Phillips, Heidi
Wallace, Mandy L.
Steffey, Michele A.
Balsa, Ingrid M.
Mayhew, Philipp D.
author_facet Griffin, Maureen A.
Culp, William T. N.
Giuffrida, Michelle A.
Selmic, Laura E.
Denitz, Jordan C.
Perry, James A.
Schoelkopf, Alexander C.
Milovancev, Milan
Phillips, Heidi
Wallace, Mandy L.
Steffey, Michele A.
Balsa, Ingrid M.
Mayhew, Philipp D.
author_sort Griffin, Maureen A.
collection PubMed
description BACKGROUND: Limited information currently exists regarding the clinical progression and outcomes of cats that undergo choledochal stenting as a treatment for extrahepatic biliary obstruction (EHBO). HYPOTHESIS/OBJECTIVES: Describe clinical characteristics, indications for choledochal stent placement, procedure, and outcomes in a cohort of cats undergoing choledochal stenting and evaluate risk factors associated with survival as well as recurrence of EHBO in affected cats. ANIMALS: Twenty‐three client‐owned cats undergoing choledochal stent placement. METHODS: Retrospective study. Medical records from 6 academic institutions were reviewed, and data were extracted and analyzed statistically. RESULTS: Median age of cats was 10.1 years (range, 2‐16), and all cats had at least 2 clinical signs. Most common clinical signs were vomiting in 20/22 (90.9%), inappetence in 19/22 (86.4%), and lethargy in 19/23 (82.6%). Procedural complications were uncommon and rarely related to the stenting procedure. Clinical signs improved postoperatively in 15/20 (75.0%) cats and serum total bilirubin concentration decreased postoperatively in 13/19 (68.4%) cats. Eighteen (78.3%) cats survived to discharge. Recurrence of EHBO was documented in 7/18 (38.9%) cats that survived to discharge. Cholelithiasis was associated with recurrence of EHBO. Median survival time for cats that survived to discharge was 931 days (range, 19‐3034). Absence of peritoneal effusion was associated with survival to discharge. CONCLUSIONS AND CLINICAL IMPORTANCE: Choledochal stenting was an effective treatment modality in cats with EHBO with few procedural complications and potential for prolonged survival, but substantial risk for recurrence of EHBO was identified.
format Online
Article
Text
id pubmed-8692206
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-86922062022-01-03 Choledochal stenting for treatment of extrahepatic biliary obstruction in cats Griffin, Maureen A. Culp, William T. N. Giuffrida, Michelle A. Selmic, Laura E. Denitz, Jordan C. Perry, James A. Schoelkopf, Alexander C. Milovancev, Milan Phillips, Heidi Wallace, Mandy L. Steffey, Michele A. Balsa, Ingrid M. Mayhew, Philipp D. J Vet Intern Med SMALL ANIMAL BACKGROUND: Limited information currently exists regarding the clinical progression and outcomes of cats that undergo choledochal stenting as a treatment for extrahepatic biliary obstruction (EHBO). HYPOTHESIS/OBJECTIVES: Describe clinical characteristics, indications for choledochal stent placement, procedure, and outcomes in a cohort of cats undergoing choledochal stenting and evaluate risk factors associated with survival as well as recurrence of EHBO in affected cats. ANIMALS: Twenty‐three client‐owned cats undergoing choledochal stent placement. METHODS: Retrospective study. Medical records from 6 academic institutions were reviewed, and data were extracted and analyzed statistically. RESULTS: Median age of cats was 10.1 years (range, 2‐16), and all cats had at least 2 clinical signs. Most common clinical signs were vomiting in 20/22 (90.9%), inappetence in 19/22 (86.4%), and lethargy in 19/23 (82.6%). Procedural complications were uncommon and rarely related to the stenting procedure. Clinical signs improved postoperatively in 15/20 (75.0%) cats and serum total bilirubin concentration decreased postoperatively in 13/19 (68.4%) cats. Eighteen (78.3%) cats survived to discharge. Recurrence of EHBO was documented in 7/18 (38.9%) cats that survived to discharge. Cholelithiasis was associated with recurrence of EHBO. Median survival time for cats that survived to discharge was 931 days (range, 19‐3034). Absence of peritoneal effusion was associated with survival to discharge. CONCLUSIONS AND CLINICAL IMPORTANCE: Choledochal stenting was an effective treatment modality in cats with EHBO with few procedural complications and potential for prolonged survival, but substantial risk for recurrence of EHBO was identified. John Wiley & Sons, Inc. 2021-09-29 2021 /pmc/articles/PMC8692206/ /pubmed/34586683 http://dx.doi.org/10.1111/jvim.16176 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle SMALL ANIMAL
Griffin, Maureen A.
Culp, William T. N.
Giuffrida, Michelle A.
Selmic, Laura E.
Denitz, Jordan C.
Perry, James A.
Schoelkopf, Alexander C.
Milovancev, Milan
Phillips, Heidi
Wallace, Mandy L.
Steffey, Michele A.
Balsa, Ingrid M.
Mayhew, Philipp D.
Choledochal stenting for treatment of extrahepatic biliary obstruction in cats
title Choledochal stenting for treatment of extrahepatic biliary obstruction in cats
title_full Choledochal stenting for treatment of extrahepatic biliary obstruction in cats
title_fullStr Choledochal stenting for treatment of extrahepatic biliary obstruction in cats
title_full_unstemmed Choledochal stenting for treatment of extrahepatic biliary obstruction in cats
title_short Choledochal stenting for treatment of extrahepatic biliary obstruction in cats
title_sort choledochal stenting for treatment of extrahepatic biliary obstruction in cats
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692206/
https://www.ncbi.nlm.nih.gov/pubmed/34586683
http://dx.doi.org/10.1111/jvim.16176
work_keys_str_mv AT griffinmaureena choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT culpwilliamtn choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT giuffridamichellea choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT selmiclaurae choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT denitzjordanc choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT perryjamesa choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT schoelkopfalexanderc choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT milovancevmilan choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT phillipsheidi choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT wallacemandyl choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT steffeymichelea choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT balsaingridm choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats
AT mayhewphilippd choledochalstentingfortreatmentofextrahepaticbiliaryobstructionincats