Cargando…

Single-Cell Transcriptome Analysis Reveals RGS1 as a New Marker and Promoting Factor for T-Cell Exhaustion in Multiple Cancers

T-cell exhaustion is one of the main reasons of tumor immune escape. Using single-cell transcriptome data of CD8+ T cells in multiple cancers, we identified different cell types, in which Pre_exhaust and exhausted T cells participated in negative regulation of immune system process. By analyzing the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bai, Yunmeng, Hu, Meiling, Chen, Zixi, Wei, Jinfen, Du, Hongli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692249/ https://www.ncbi.nlm.nih.gov/pubmed/34956194 http://dx.doi.org/10.3389/fimmu.2021.767070

Ejemplares similares

Characterization of Glycolysis-Associated Molecules in the Tumor Microenvironment Revealed by Pan-Cancer Tissues and Lung Cancer Single Cell Data
por: Wei, Jinfen, et al.
Publicado: (2020)

Single-cell transcriptome analysis reveals T-cell exhaustion in denosumab-treated giant cell tumor of bone
por: Yang, Meiling, et al.
Publicado: (2022)

Characterizing Intercellular Communication of Pan-Cancer Reveals SPP1+ Tumor-Associated Macrophage Expanded in Hypoxia and Promoting Cancer Malignancy Through Single-Cell RNA-Seq Data
por: Wei, Jinfen, et al.
Publicado: (2021)

Improving Cancer Immunotherapy: Exploring and Targeting Metabolism in Hypoxia Microenvironment
por: Wei, Jinfen, et al.
Publicado: (2022)

Single-Cell Transcriptomics of Immune Cells Reveal Diversity and Exhaustion Signatures in Non-Small-Cell Lung Cancer
por: Zhao, Ying, et al.
Publicado: (2022)

Single‐cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers
por: Wei, Jinfen, et al.
Publicado: (2023)

Analyses of Long-Term Epidemic Trends and Evolution Characteristics of Haplotype Subtypes Reveal the Dynamic Selection on SARS-CoV-2
por: Xi, Binbin, et al.
Publicado: (2022)

scWizard: A web-based automated tool for classifying and annotating single cells and downstream analysis of single-cell RNA-seq data in cancers
por: Wei, Jinfen, et al.
Publicado: (2022)

Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm
por: DePasquale, Erica A. K., et al.
Publicado: (2022)

Comprehensive evolution and molecular characteristics of a large number of SARS-CoV-2 genomes reveal its epidemic trends
por: Bai, Yunmeng, et al.
Publicado: (2020)

Single-Cell Transcriptomic Analysis Reveals the Crosstalk Propensity Between the Tumor Intermediate State and the CD8+ T Exhausted State to be Associated with Clinical Benefits in Melanoma
por: Zhu, Jiali, et al.
Publicado: (2022)

Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment
por: McRitchie, Bayley R., et al.
Publicado: (2022)

NK Cell Exhaustion
por: Bi, Jiacheng, et al.
Publicado: (2017)

Editorial: T Cell Exhaustion
por: Bonorino, Cristina, et al.
Publicado: (2020)

Intercellular Molecular Crosstalk Networks within Invasive and Immunosuppressive Tumor Microenvironment Subtypes Associated with Clinical Outcomes in Four Cancer Types
por: Wei, Jinfen, et al.
Publicado: (2023)

Integrated analysis of multi-omics data reveals T cell exhaustion in sepsis
por: Li, Qiaoke, et al.
Publicado: (2023)

Single-cell transcriptome sequencing reveals tumor heterogeneity in family neuroblastoma
por: Zhang, Yunlong, et al.
Publicado: (2023)

Markers of Immune Cell Exhaustion as Predictor of Survival in Surgically-Treated Early-Stage NSCLC
por: Sellmer, Laura, et al.
Publicado: (2022)

Malaria drives T cells to exhaustion
por: Wykes, Michelle N., et al.
Publicado: (2014)

Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion
por: Wu, Yingcheng, et al.
Publicado: (2019)

Single‐cell transcriptome profiling reveals the key role of ZNF683 in natural killer cell exhaustion in multiple myeloma
por: Li, Xin, et al.
Publicado: (2022)

Transcriptome and single-cell analysis reveal the contribution of immunosuppressive microenvironment for promoting glioblastoma progression
por: Ni, Lulu, et al.
Publicado: (2023)

Single-Cell Transcriptome Profiling Reveals Neutrophil Heterogeneity and Functional Multiplicity in the Early Stage of Severe Burn Patients
por: Huang, Jiamin, et al.
Publicado: (2022)

An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics
por: Wang, Shaobo, et al.
Publicado: (2020)

Monitoring of kinetics and exhaustion markers of circulating CAR-T cells as early predictive factors in patients with B-cell malignancies
por: García-Calderón, Clara Beatriz, et al.
Publicado: (2023)

Dynamic Network Biomarker of Pre-Exhausted CD8(+) T Cells Contributed to T Cell Exhaustion in Colorectal Cancer
por: Hu, Jiaqi, et al.
Publicado: (2021)

Neutrophil Extracellular Traps Promote T Cell Exhaustion in the Tumor Microenvironment
por: Kaltenmeier, Christof, et al.
Publicado: (2021)

Inhibitory Receptors Beyond T Cell Exhaustion
por: Fuertes Marraco, Silvia A., et al.
Publicado: (2015)

Is There a Positive Side to T Cell Exhaustion?
por: Pawelec, Graham
Publicado: (2019)

CD8(+) T Cell Exhaustion in Cancer
por: Dolina, Joseph S., et al.
Publicado: (2021)

NK cell exhaustion in the tumor microenvironment
por: Jia, Hao, et al.
Publicado: (2023)

A score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancer
por: Ding, Ke, et al.
Publicado: (2022)

Circulating T Cell Activation and Exhaustion Markers Are Associated With Radiation Pneumonitis and Poor Survival in Non-Small-Cell Lung Cancer
por: Berg, Janna, et al.
Publicado: (2022)

Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy
por: Zheng, Ping, et al.
Publicado: (2023)

B7-H7 Is Inducible on T Cells to Regulate Their Immune Response and Serves as a Marker for Exhaustion
por: Luu, Khang, et al.
Publicado: (2021)

T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses
por: Saeidi, Alireza, et al.
Publicado: (2018)

RGS10 Reduces Lethal Influenza Infection and Associated Lung Inflammation in Mice
por: Almutairi, Faris, et al.
Publicado: (2021)

Single-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signatures
por: Wang, Xiaonan, et al.
Publicado: (2021)

Single cell transcriptome analyses reveal the roles of B cells in fructose-induced hypertension
por: Kim, Cheong-Wun, et al.
Publicado: (2023)

Corrigendum: Circulating T cell activation and exhaustion markers are associated with radiation pneumonitis and poor survival in non-small-cell lung cancer
por: Berg, Janna, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nac2hvuindi7vhrblvvn0ljla9