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Combination of Early Allograft Dysfunction and Protein Expression Patterns Predicts Outcome of Liver Transplantation From Donation After Cardiac Death

Early allograft dysfunction (EAD) after liver transplantation (LT) accompanies poor prognosis. This study aims to explore the relationship between pretransplant intrahepatic proteins and the incidence of EAD, and the value of combined EAD and protein profiles for predicting recipient and graft survi...

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Autores principales: Wei, Qiang, Zhou, Junbin, Wang, Kun, Zhang, Xuanyu, Chen, Junli, Lu, Di, Wei, Xuyong, Zheng, Shusen, Xu, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692269/
https://www.ncbi.nlm.nih.gov/pubmed/34957150
http://dx.doi.org/10.3389/fmed.2021.775212
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author Wei, Qiang
Zhou, Junbin
Wang, Kun
Zhang, Xuanyu
Chen, Junli
Lu, Di
Wei, Xuyong
Zheng, Shusen
Xu, Xiao
author_facet Wei, Qiang
Zhou, Junbin
Wang, Kun
Zhang, Xuanyu
Chen, Junli
Lu, Di
Wei, Xuyong
Zheng, Shusen
Xu, Xiao
author_sort Wei, Qiang
collection PubMed
description Early allograft dysfunction (EAD) after liver transplantation (LT) accompanies poor prognosis. This study aims to explore the relationship between pretransplant intrahepatic proteins and the incidence of EAD, and the value of combined EAD and protein profiles for predicting recipient and graft survival prognosis. Liver biopsy specimens of 105 pretransplant grafts used for LT were collected and used for immunohistochemistry analysis of 5 proteins. And matched clinical data of donor, recipient, transplantation, and prognosis were analyzed. The incidence of EAD was 41.9% (44/105) in this cohort. Macrovesicular steatosis (P = 0.016), donor body mass index (P = 0.013), recipients' pretransplant serum creatinine (P = 0.036), and intrahepatic expression of heme oxygenase 1 (HO1) (P = 0.015) and tumor necrosis factor α (TNF-α) (P = 0.039) were independent predictors of EAD. Inferior graft and recipient prognosis were observed in patients who experienced EAD (P = 0.028 and 0.031) or received grafts with higher expression of sirtuin 1 (P = 0.005 and 0.013). The graft and recipient survival were worst in patients with both EAD and high expression of sirtuin 1 (P = 0.001 and 0.004). In conclusion, pretransplant intrahepatic expression of HO1 and TNF-α are associated with the incidence of EAD. The combination of EAD and EAD-unrelated proteins showed superiority in distinguishing recipients with worse prognosis.
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spelling pubmed-86922692021-12-23 Combination of Early Allograft Dysfunction and Protein Expression Patterns Predicts Outcome of Liver Transplantation From Donation After Cardiac Death Wei, Qiang Zhou, Junbin Wang, Kun Zhang, Xuanyu Chen, Junli Lu, Di Wei, Xuyong Zheng, Shusen Xu, Xiao Front Med (Lausanne) Medicine Early allograft dysfunction (EAD) after liver transplantation (LT) accompanies poor prognosis. This study aims to explore the relationship between pretransplant intrahepatic proteins and the incidence of EAD, and the value of combined EAD and protein profiles for predicting recipient and graft survival prognosis. Liver biopsy specimens of 105 pretransplant grafts used for LT were collected and used for immunohistochemistry analysis of 5 proteins. And matched clinical data of donor, recipient, transplantation, and prognosis were analyzed. The incidence of EAD was 41.9% (44/105) in this cohort. Macrovesicular steatosis (P = 0.016), donor body mass index (P = 0.013), recipients' pretransplant serum creatinine (P = 0.036), and intrahepatic expression of heme oxygenase 1 (HO1) (P = 0.015) and tumor necrosis factor α (TNF-α) (P = 0.039) were independent predictors of EAD. Inferior graft and recipient prognosis were observed in patients who experienced EAD (P = 0.028 and 0.031) or received grafts with higher expression of sirtuin 1 (P = 0.005 and 0.013). The graft and recipient survival were worst in patients with both EAD and high expression of sirtuin 1 (P = 0.001 and 0.004). In conclusion, pretransplant intrahepatic expression of HO1 and TNF-α are associated with the incidence of EAD. The combination of EAD and EAD-unrelated proteins showed superiority in distinguishing recipients with worse prognosis. Frontiers Media S.A. 2021-12-08 /pmc/articles/PMC8692269/ /pubmed/34957150 http://dx.doi.org/10.3389/fmed.2021.775212 Text en Copyright © 2021 Wei, Zhou, Wang, Zhang, Chen, Lu, Wei, Zheng and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Wei, Qiang
Zhou, Junbin
Wang, Kun
Zhang, Xuanyu
Chen, Junli
Lu, Di
Wei, Xuyong
Zheng, Shusen
Xu, Xiao
Combination of Early Allograft Dysfunction and Protein Expression Patterns Predicts Outcome of Liver Transplantation From Donation After Cardiac Death
title Combination of Early Allograft Dysfunction and Protein Expression Patterns Predicts Outcome of Liver Transplantation From Donation After Cardiac Death
title_full Combination of Early Allograft Dysfunction and Protein Expression Patterns Predicts Outcome of Liver Transplantation From Donation After Cardiac Death
title_fullStr Combination of Early Allograft Dysfunction and Protein Expression Patterns Predicts Outcome of Liver Transplantation From Donation After Cardiac Death
title_full_unstemmed Combination of Early Allograft Dysfunction and Protein Expression Patterns Predicts Outcome of Liver Transplantation From Donation After Cardiac Death
title_short Combination of Early Allograft Dysfunction and Protein Expression Patterns Predicts Outcome of Liver Transplantation From Donation After Cardiac Death
title_sort combination of early allograft dysfunction and protein expression patterns predicts outcome of liver transplantation from donation after cardiac death
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692269/
https://www.ncbi.nlm.nih.gov/pubmed/34957150
http://dx.doi.org/10.3389/fmed.2021.775212
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