Cargando…

Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis

Insomnia disorder (ID) is a heterogeneous disorder with proposed subtypes based on objective sleep duration. We speculated that insomnia subtyping with additional power spectral analysis and measurement of response to acute sleep restriction may be informative in overall assessment of ID. To explore...

Descripción completa

Detalles Bibliográficos
Autores principales: Kao, Chien-Hui, D’Rozario, Angela L., Lovato, Nicole, Wassing, Rick, Bartlett, Delwyn, Memarian, Negar, Espinel, Paola, Kim, Jong-Won, Grunstein, Ronald R., Gordon, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692344/
https://www.ncbi.nlm.nih.gov/pubmed/34934082
http://dx.doi.org/10.1038/s41598-021-03564-6
_version_ 1784618938334707712
author Kao, Chien-Hui
D’Rozario, Angela L.
Lovato, Nicole
Wassing, Rick
Bartlett, Delwyn
Memarian, Negar
Espinel, Paola
Kim, Jong-Won
Grunstein, Ronald R.
Gordon, Christopher J.
author_facet Kao, Chien-Hui
D’Rozario, Angela L.
Lovato, Nicole
Wassing, Rick
Bartlett, Delwyn
Memarian, Negar
Espinel, Paola
Kim, Jong-Won
Grunstein, Ronald R.
Gordon, Christopher J.
author_sort Kao, Chien-Hui
collection PubMed
description Insomnia disorder (ID) is a heterogeneous disorder with proposed subtypes based on objective sleep duration. We speculated that insomnia subtyping with additional power spectral analysis and measurement of response to acute sleep restriction may be informative in overall assessment of ID. To explore alternative classifications of ID subtypes, insomnia patients (n = 99) underwent two consecutive overnight sleep studies: (i) habitual sleep opportunity (polysomnography, PSG) and, (ii) two hours less sleep opportunity (electroencephalography, EEG), with the first night compared to healthy controls (n = 25). ID subtypes were derived from data-driven classification of PSG, EEG spectral power and interhemispheric EEG asymmetry index. Three insomnia subtypes with different sleep duration and NREM spectral power were identified. One subtype (n = 26) had shorter sleep duration and lower NREM delta power than healthy controls (short-sleep delta-deficient; SSDD), the second subtype (n = 51) had normal sleep duration but lower NREM delta power than healthy controls (normal-sleep delta-deficient; NSDD) and a third subtype showed (n = 22) no difference in sleep duration or delta power from healthy controls (normal neurophysiological sleep; NNS). Acute sleep restriction improved multiple objective sleep measures across all insomnia subtypes including increased delta power in SSDD and NSDD, and improvements in subjective sleep quality for SSDD (p = 0.03), with a trend observed for NSDD (p = 0.057). These exploratory results suggest evidence of novel neurophysiological insomnia subtypes that may inform sleep state misperception in ID and with further research, may provide pathways for personalised care.
format Online
Article
Text
id pubmed-8692344
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-86923442021-12-22 Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis Kao, Chien-Hui D’Rozario, Angela L. Lovato, Nicole Wassing, Rick Bartlett, Delwyn Memarian, Negar Espinel, Paola Kim, Jong-Won Grunstein, Ronald R. Gordon, Christopher J. Sci Rep Article Insomnia disorder (ID) is a heterogeneous disorder with proposed subtypes based on objective sleep duration. We speculated that insomnia subtyping with additional power spectral analysis and measurement of response to acute sleep restriction may be informative in overall assessment of ID. To explore alternative classifications of ID subtypes, insomnia patients (n = 99) underwent two consecutive overnight sleep studies: (i) habitual sleep opportunity (polysomnography, PSG) and, (ii) two hours less sleep opportunity (electroencephalography, EEG), with the first night compared to healthy controls (n = 25). ID subtypes were derived from data-driven classification of PSG, EEG spectral power and interhemispheric EEG asymmetry index. Three insomnia subtypes with different sleep duration and NREM spectral power were identified. One subtype (n = 26) had shorter sleep duration and lower NREM delta power than healthy controls (short-sleep delta-deficient; SSDD), the second subtype (n = 51) had normal sleep duration but lower NREM delta power than healthy controls (normal-sleep delta-deficient; NSDD) and a third subtype showed (n = 22) no difference in sleep duration or delta power from healthy controls (normal neurophysiological sleep; NNS). Acute sleep restriction improved multiple objective sleep measures across all insomnia subtypes including increased delta power in SSDD and NSDD, and improvements in subjective sleep quality for SSDD (p = 0.03), with a trend observed for NSDD (p = 0.057). These exploratory results suggest evidence of novel neurophysiological insomnia subtypes that may inform sleep state misperception in ID and with further research, may provide pathways for personalised care. Nature Publishing Group UK 2021-12-21 /pmc/articles/PMC8692344/ /pubmed/34934082 http://dx.doi.org/10.1038/s41598-021-03564-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kao, Chien-Hui
D’Rozario, Angela L.
Lovato, Nicole
Wassing, Rick
Bartlett, Delwyn
Memarian, Negar
Espinel, Paola
Kim, Jong-Won
Grunstein, Ronald R.
Gordon, Christopher J.
Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis
title Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis
title_full Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis
title_fullStr Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis
title_full_unstemmed Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis
title_short Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis
title_sort insomnia subtypes characterised by objective sleep duration and nrem spectral power and the effect of acute sleep restriction: an exploratory analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692344/
https://www.ncbi.nlm.nih.gov/pubmed/34934082
http://dx.doi.org/10.1038/s41598-021-03564-6
work_keys_str_mv AT kaochienhui insomniasubtypescharacterisedbyobjectivesleepdurationandnremspectralpowerandtheeffectofacutesleeprestrictionanexploratoryanalysis
AT drozarioangelal insomniasubtypescharacterisedbyobjectivesleepdurationandnremspectralpowerandtheeffectofacutesleeprestrictionanexploratoryanalysis
AT lovatonicole insomniasubtypescharacterisedbyobjectivesleepdurationandnremspectralpowerandtheeffectofacutesleeprestrictionanexploratoryanalysis
AT wassingrick insomniasubtypescharacterisedbyobjectivesleepdurationandnremspectralpowerandtheeffectofacutesleeprestrictionanexploratoryanalysis
AT bartlettdelwyn insomniasubtypescharacterisedbyobjectivesleepdurationandnremspectralpowerandtheeffectofacutesleeprestrictionanexploratoryanalysis
AT memariannegar insomniasubtypescharacterisedbyobjectivesleepdurationandnremspectralpowerandtheeffectofacutesleeprestrictionanexploratoryanalysis
AT espinelpaola insomniasubtypescharacterisedbyobjectivesleepdurationandnremspectralpowerandtheeffectofacutesleeprestrictionanexploratoryanalysis
AT kimjongwon insomniasubtypescharacterisedbyobjectivesleepdurationandnremspectralpowerandtheeffectofacutesleeprestrictionanexploratoryanalysis
AT grunsteinronaldr insomniasubtypescharacterisedbyobjectivesleepdurationandnremspectralpowerandtheeffectofacutesleeprestrictionanexploratoryanalysis
AT gordonchristopherj insomniasubtypescharacterisedbyobjectivesleepdurationandnremspectralpowerandtheeffectofacutesleeprestrictionanexploratoryanalysis