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Combined effects of double mutations on catalytic activity and structural stability contribute to clinical manifestations of glucose-6-phosphate dehydrogenase deficiency

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans, affecting ~ 500 million worldwide. A detailed study of the structural stability and catalytic activity of G6PD variants is required to understand how different mutations cause varying degrees of enzyme defi...

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Detalles Bibliográficos
Autores principales:	Pakparnich, Phonchanan, Sudsumrit, Sirapapha, Imwong, Mallika, Suteewong, Teeraporn, Chamchoy, Kamonwan, Pakotiprapha, Danaya, Leartsakulpanich, Ubolsree, Boonyuen, Usa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692357/ https://www.ncbi.nlm.nih.gov/pubmed/34934109 http://dx.doi.org/10.1038/s41598-021-03800-z

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