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Programmable Base Editing in Mycobacterium tuberculosis Using an Engineered CRISPR RNA-Guided Cytidine Deaminase

Multidrug-resistant Mycobacterium tuberculosis (Mtb) infection seriously endangers global human health, creating an urgent need for new treatment strategies. Efficient genome editing tools can facilitate identification of key genes and pathways involved in bacterial physiology, pathogenesis, and dru...

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Detalles Bibliográficos
Autores principales:	Ding, Xin-Yuan, Li, Si-Shang, Geng, Yi-Man, Yan, Mei-Yi, Li, Guo-Bao, Zhang, Guo-Liang, Sun, Yi-Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Genome Editing
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692370/ https://www.ncbi.nlm.nih.gov/pubmed/34957465 http://dx.doi.org/10.3389/fgeed.2021.734436

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