A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells

Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many solid tumors as ALDHs may regulate cell proliferation and chemoresistance of cancer stem cells (CSCs). Accordingly, potent, and selective inhibitors of key ALDH enzymes may represent a novel CSC-directed treatment...

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Detalles Bibliográficos
Autores principales: Li, Jianfeng, Garavaglia, Silvia, Ye, Zhaofeng, Moretti, Andrea, Belyaeva, Olga V., Beiser, Alison, Ibrahim, Md, Wilk, Anna, McClellan, Steve, Klyuyeva, Alla V., Goggans, Kelli R., Kedishvili, Natalia Y., Salter, E. Alan, Wierzbicki, Andrzej, Migaud, Marie E., Mullett, Steven J., Yates, Nathan A., Camacho, Carlos J., Rizzi, Menico, Sobol, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692581/
https://www.ncbi.nlm.nih.gov/pubmed/34934174
http://dx.doi.org/10.1038/s42003-021-02949-7

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