MEK inhibition exerts temporal and myeloid cell-specific effects in the pathogenesis of neurofibromatosis type 1 arteriopathy

Mutations in the NF1 tumor suppressor gene are linked to arteriopathy. Nf1 heterozygosity (Nf1+/–) results in robust neointima formation, similar to humans, and myeloid-restricted Nf1+/– recapitulates this phenotype via MEK-ERK activation. Here we define the contribution of myeloid subpopulations to...

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Detalles Bibliográficos
Autores principales: Tritz, Rebekah, Hudson, Farlyn Z., Harris, Valerie, Ghoshal, Pushpankur, Singla, Bhupesh, Lin, Huiping, Csanyi, Gabor, Stansfield, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692602/
https://www.ncbi.nlm.nih.gov/pubmed/34934133
http://dx.doi.org/10.1038/s41598-021-03750-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692602/
https://www.ncbi.nlm.nih.gov/pubmed/34934133
http://dx.doi.org/10.1038/s41598-021-03750-6

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