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Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles
Diversity scaling (changes) of human gut microbiome is important because it measures the inter-individual heterogeneity of diversity and other important parameters of population-level diversity. Understanding the heterogeneity of microbial diversity can be used as a reference for the personalized me...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692740/ https://www.ncbi.nlm.nih.gov/pubmed/34956110 http://dx.doi.org/10.3389/fmicb.2021.736393 |
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author | Xiao, Wanmeng Gao, Depei Chen, Hongju (Daisy) Qiao, Yuting Ma, Zhanshan (Sam) Duan, Lincan |
author_facet | Xiao, Wanmeng Gao, Depei Chen, Hongju (Daisy) Qiao, Yuting Ma, Zhanshan (Sam) Duan, Lincan |
author_sort | Xiao, Wanmeng |
collection | PubMed |
description | Diversity scaling (changes) of human gut microbiome is important because it measures the inter-individual heterogeneity of diversity and other important parameters of population-level diversity. Understanding the heterogeneity of microbial diversity can be used as a reference for the personalized medicine of microbiome-associated diseases. Similar to diversity per se, diversity scaling may also be influenced by host factors, especially lifestyles and ethnicities. Nevertheless, this important topic regarding Chinese populations has not been addressed, to our best knowledge. Here, we fill the gap by applying a recent extension to the classic species–area relationship (SAR), i.e., diversity–area relationship (DAR), to reanalyze a large dataset of Chinese gut microbiomes covering the seven biggest Chinese ethnic groups (covering > 95% Chinese) living rural and urban lifestyles. Four DAR profiles were constructed to investigate the diversity scaling, diversity overlap, potential maximal diversity, and the ratio of local to global diversity of Chinese gut microbiomes. We discovered the following: (i) The diversity scaling parameters (z) at various taxon levels are little affected by either ethnicity or lifestyles, as exhibited by less than 0.5% differences in pairwise comparisons. (ii) The maximal accrual diversity (potential diversity) exhibited difference in only about 5% of pairwise comparisons, and all of the differences occurred in ethnicity comparisons (i.e., lifestyles had no effects). (iii) Ethnicity seems to have stronger effects than lifestyles across all taxon levels, and this may reflect the reality that China has been experiencing rapid urbanization in the last few decades, while the ethnic-related genetic background may change relatively little during the same period. |
format | Online Article Text |
id | pubmed-8692740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86927402021-12-23 Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles Xiao, Wanmeng Gao, Depei Chen, Hongju (Daisy) Qiao, Yuting Ma, Zhanshan (Sam) Duan, Lincan Front Microbiol Microbiology Diversity scaling (changes) of human gut microbiome is important because it measures the inter-individual heterogeneity of diversity and other important parameters of population-level diversity. Understanding the heterogeneity of microbial diversity can be used as a reference for the personalized medicine of microbiome-associated diseases. Similar to diversity per se, diversity scaling may also be influenced by host factors, especially lifestyles and ethnicities. Nevertheless, this important topic regarding Chinese populations has not been addressed, to our best knowledge. Here, we fill the gap by applying a recent extension to the classic species–area relationship (SAR), i.e., diversity–area relationship (DAR), to reanalyze a large dataset of Chinese gut microbiomes covering the seven biggest Chinese ethnic groups (covering > 95% Chinese) living rural and urban lifestyles. Four DAR profiles were constructed to investigate the diversity scaling, diversity overlap, potential maximal diversity, and the ratio of local to global diversity of Chinese gut microbiomes. We discovered the following: (i) The diversity scaling parameters (z) at various taxon levels are little affected by either ethnicity or lifestyles, as exhibited by less than 0.5% differences in pairwise comparisons. (ii) The maximal accrual diversity (potential diversity) exhibited difference in only about 5% of pairwise comparisons, and all of the differences occurred in ethnicity comparisons (i.e., lifestyles had no effects). (iii) Ethnicity seems to have stronger effects than lifestyles across all taxon levels, and this may reflect the reality that China has been experiencing rapid urbanization in the last few decades, while the ethnic-related genetic background may change relatively little during the same period. Frontiers Media S.A. 2021-12-08 /pmc/articles/PMC8692740/ /pubmed/34956110 http://dx.doi.org/10.3389/fmicb.2021.736393 Text en Copyright © 2021 Xiao, Gao, Chen, Qiao, Ma and Duan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Xiao, Wanmeng Gao, Depei Chen, Hongju (Daisy) Qiao, Yuting Ma, Zhanshan (Sam) Duan, Lincan Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles |
title | Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles |
title_full | Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles |
title_fullStr | Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles |
title_full_unstemmed | Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles |
title_short | Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles |
title_sort | diversity scaling analysis of chinese gut microbiomes across ethnicities and lifestyles |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692740/ https://www.ncbi.nlm.nih.gov/pubmed/34956110 http://dx.doi.org/10.3389/fmicb.2021.736393 |
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