Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation

Rationale: We found that a subset of signal transducer and activator of transcription 3 (STAT3) translocated into mitochondria in phagocytes, including macrophages isolated from individuals with sepsis. However, the role of mitochondrial STAT3 in macrophages remains unclear. Method: To investigate t...

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Detalles Bibliográficos
Autores principales: Li, Rongqing, Li, Xueqin, Zhao, Jie, Meng, Fandong, Yao, Chen, Bao, Ensi, Sun, Na, Chen, Xin, Cheng, Wanpeng, Hua, Hui, Li, Xiangyang, Wang, Bo, Wang, Hui, Pan, Xiucheng, You, Hongjuan, Yang, Jing, Ikezoe, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692896/
https://www.ncbi.nlm.nih.gov/pubmed/34976224
http://dx.doi.org/10.7150/thno.63751

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