Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3

Of the family of polyglutamine (polyQ) neurodegenerative diseases, Spinocerebellar Ataxia Type 3 (SCA3) is the most common. Like other polyQ diseases, SCA3 stems from abnormal expansions in the CAG triplet repeat of its disease gene resulting in elongated polyQ repeats within its protein, ataxin-3....

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Detalles Bibliográficos
Autores principales: Johnson, Sean L., Libohova, Kozeta, Blount, Jessica R., Sujkowski, Alyson L., Prifti, Matthew V., Tsou, Wei-Ling, Todi, Sokol V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693084/
https://www.ncbi.nlm.nih.gov/pubmed/34563642
http://dx.doi.org/10.1016/j.nbd.2021.105516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693084/
https://www.ncbi.nlm.nih.gov/pubmed/34563642
http://dx.doi.org/10.1016/j.nbd.2021.105516

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