Protein Removal from Hydrogels through Repetitive Surface Degradation

[Image: see text] Suppression of protein adsorption is a necessary property for materials used in the living body. In this study, thermoresponsive and degradable hydrogels were prepared by the radical polymerization of 2-methylene-1,3-dioxepane, 2-hydroxyethyl acrylate (HEA), and poly(ethylene glyco...

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Autores principales: Kamiya, Tatsuki, Komatsu, Syuuhei, Kikuchi, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693177/
https://www.ncbi.nlm.nih.gov/pubmed/35005931
http://dx.doi.org/10.1021/acsabm.1c00993
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author Kamiya, Tatsuki
Komatsu, Syuuhei
Kikuchi, Akihiko
author_facet Kamiya, Tatsuki
Komatsu, Syuuhei
Kikuchi, Akihiko
author_sort Kamiya, Tatsuki
collection PubMed
description [Image: see text] Suppression of protein adsorption is a necessary property for materials used in the living body. In this study, thermoresponsive and degradable hydrogels were prepared by the radical polymerization of 2-methylene-1,3-dioxepane, 2-hydroxyethyl acrylate (HEA), and poly(ethylene glycol) monomethacrylate (PEGMA). The prepared hydrogels re-exposed PEG-grafted chains to the interface through surface degradation, which was confirmed by the maintenance of the chemical composition of the hydrogel surfaces after hydrolysis. Notably, adsorbed proteins can be removed from the hydrogel surfaces through hydrogel surface degradation at least thrice.
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spelling pubmed-86931772021-12-22 Protein Removal from Hydrogels through Repetitive Surface Degradation Kamiya, Tatsuki Komatsu, Syuuhei Kikuchi, Akihiko ACS Appl Bio Mater [Image: see text] Suppression of protein adsorption is a necessary property for materials used in the living body. In this study, thermoresponsive and degradable hydrogels were prepared by the radical polymerization of 2-methylene-1,3-dioxepane, 2-hydroxyethyl acrylate (HEA), and poly(ethylene glycol) monomethacrylate (PEGMA). The prepared hydrogels re-exposed PEG-grafted chains to the interface through surface degradation, which was confirmed by the maintenance of the chemical composition of the hydrogel surfaces after hydrolysis. Notably, adsorbed proteins can be removed from the hydrogel surfaces through hydrogel surface degradation at least thrice. American Chemical Society 2021-11-19 2021-12-20 /pmc/articles/PMC8693177/ /pubmed/35005931 http://dx.doi.org/10.1021/acsabm.1c00993 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Kamiya, Tatsuki
Komatsu, Syuuhei
Kikuchi, Akihiko
Protein Removal from Hydrogels through Repetitive Surface Degradation
title Protein Removal from Hydrogels through Repetitive Surface Degradation
title_full Protein Removal from Hydrogels through Repetitive Surface Degradation
title_fullStr Protein Removal from Hydrogels through Repetitive Surface Degradation
title_full_unstemmed Protein Removal from Hydrogels through Repetitive Surface Degradation
title_short Protein Removal from Hydrogels through Repetitive Surface Degradation
title_sort protein removal from hydrogels through repetitive surface degradation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693177/
https://www.ncbi.nlm.nih.gov/pubmed/35005931
http://dx.doi.org/10.1021/acsabm.1c00993
work_keys_str_mv AT kamiyatatsuki proteinremovalfromhydrogelsthroughrepetitivesurfacedegradation
AT komatsusyuuhei proteinremovalfromhydrogelsthroughrepetitivesurfacedegradation
AT kikuchiakihiko proteinremovalfromhydrogelsthroughrepetitivesurfacedegradation

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