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Investigation of PAS and CNBH domain interactions in hERG channels and effects of long-QT syndrome-causing mutations with surface plasmon resonance

Human ether-á-go-go-related gene (hERG) channels are key regulators of cardiac repolarization, neuronal excitability, and tumorigenesis. hERG channels contain N-terminal Per-Arnt-Sim (PAS) and C-terminal cyclic nucleotide-binding homology (CNBH) domains with many long-QT syndrome (LQTS)-causing muta...

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Detalles Bibliográficos
Autores principales:	Soohoo, Stephanie M., Tiwari, Purushottam B., Suzuki, Yuichiro J., Brelidze, Tinatin I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693265/ https://www.ncbi.nlm.nih.gov/pubmed/34801551 http://dx.doi.org/10.1016/j.jbc.2021.101433

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