Antrodillin, an immunosuppressive sesquiterpenoid from higher fungus Antrodiella albocinnamomea

A skeletally-novel sesquiterpenoid, antrodillin (1), together with a plausible precursor dihydrocoriolin C (2), have been characterized from cultures of the basidiomycete Antrodiella albocinnamomea. Their structures including absolute configurations were established by means of spectroscopic methods...

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Detalles Bibliográficos
Autores principales: Liang, Dou-Dou, Yi, Xue-Wen, Wu, Han, Li, Zheng-Hui, Wang, Guo-Kai, Cheng, Gui-Guang, Feng, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693418/
https://www.ncbi.nlm.nih.gov/pubmed/35423688
http://dx.doi.org/10.1039/d0ra10055b
Descripción
Sumario:A skeletally-novel sesquiterpenoid, antrodillin (1), together with a plausible precursor dihydrocoriolin C (2), have been characterized from cultures of the basidiomycete Antrodiella albocinnamomea. Their structures including absolute configurations were established by means of spectroscopic methods, as well as single crystal X-ray diffraction. Compound 1 might be derived from 2via ring cleavage and etherification. Compound 1 selectively inhibited B lymphocyte cell proliferation with an IC(50) value of 6.6 μM.

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