Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory

PD-1/PD-L1 checkpoint blockade has achieved unprecedented success in cancer immunotherapy. Nevertheless, many immune-excluded tumors are resistant to therapy. Combination with oncolytic virotherapy may overcome resistance by inducing acute inflammation, immune cell recruitment, and remodeling of the...

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Detalles Bibliográficos
Autores principales: Veinalde, Rūta, Pidelaserra-Martí, Gemma, Moulin, Coline, Jeworowski, Lara M., Küther, Linda, Buchholz, Christian J., Jäger, Dirk, Ungerechts, Guy, Engeland, Christine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693420/
https://www.ncbi.nlm.nih.gov/pubmed/34977341
http://dx.doi.org/10.1016/j.omto.2021.11.020

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