Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, human papillomavirus (HPV) status, and sensitivity to tyrosine kinase inhibitors

BACKGROUND: Dysregulation of fibroblast growth factor receptor (FGFR) signaling pathway has been observed in head and neck squamous cell carcinoma (HNSCC) and is a promising therapeutic target for selective tyrosine kinase inhibitors (TKIs). Potential predictive biomarkers for response to FGFR-targe...

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Detalles Bibliográficos
Autores principales: Bao, Yilin, Gabrielpillai, Jennis, Dietrich, Jörn, Zarbl, Romina, Strieth, Sebastian, Schröck, Friederike, Dietrich, Dimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693503/
https://www.ncbi.nlm.nih.gov/pubmed/34933671
http://dx.doi.org/10.1186/s13148-021-01212-4

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