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Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients

Introduction: Preservation of language functioning in patients undergoing brain tumor surgery is essential because language impairments negatively impact the quality of life. Brain tumor patients have alterations in functional connectivity (FC), the extent to which brain areas functionally interact....

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Autores principales: Wolthuis, Nienke, Satoer, Djaina, Veenstra, Wencke, Smits, Marion, Wagemakers, Michiel, Vincent, Arnaud, Bastiaanse, Roelien, Cherian, Perumpillichira J., Bosma, Ingeborg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693574/
https://www.ncbi.nlm.nih.gov/pubmed/34955732
http://dx.doi.org/10.3389/fnins.2021.785969
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author Wolthuis, Nienke
Satoer, Djaina
Veenstra, Wencke
Smits, Marion
Wagemakers, Michiel
Vincent, Arnaud
Bastiaanse, Roelien
Cherian, Perumpillichira J.
Bosma, Ingeborg
author_facet Wolthuis, Nienke
Satoer, Djaina
Veenstra, Wencke
Smits, Marion
Wagemakers, Michiel
Vincent, Arnaud
Bastiaanse, Roelien
Cherian, Perumpillichira J.
Bosma, Ingeborg
author_sort Wolthuis, Nienke
collection PubMed
description Introduction: Preservation of language functioning in patients undergoing brain tumor surgery is essential because language impairments negatively impact the quality of life. Brain tumor patients have alterations in functional connectivity (FC), the extent to which brain areas functionally interact. We studied FC networks in relation to language functioning in glioma and meningioma patients. Method: Patients with a low-grade glioma (N = 15) or meningioma (N = 10) infiltrating into/pressing on the language-dominant hemisphere underwent extensive language testing before and 1 year after surgery. Resting-state EEG was registered preoperatively, postoperatively (glioma patients only), and once in healthy individuals. After analyzing FC in theta and alpha frequency bands, weighted networks and Minimum Spanning Trees were quantified by various network measures. Results: Pre-operative FC network characteristics did not differ between glioma patients and healthy individuals. However, hub presence and higher local and global FC are associated with poorer language functioning before surgery in glioma patients and predict worse language performance at 1 year after surgery. For meningioma patients, a greater small worldness was related to worse language performance and hub presence; better average clustering and global integration were predictive of worse outcome on language function 1 year after surgery. The average eccentricity, diameter and tree hierarchy seem to be the network metrics with the more pronounced relation to language performance. Discussion: In this exploratory study, we demonstrated that preoperative FC networks are informative for pre- and postoperative language functioning in glioma patients and to a lesser extent in meningioma patients.
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spelling pubmed-86935742021-12-23 Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients Wolthuis, Nienke Satoer, Djaina Veenstra, Wencke Smits, Marion Wagemakers, Michiel Vincent, Arnaud Bastiaanse, Roelien Cherian, Perumpillichira J. Bosma, Ingeborg Front Neurosci Neuroscience Introduction: Preservation of language functioning in patients undergoing brain tumor surgery is essential because language impairments negatively impact the quality of life. Brain tumor patients have alterations in functional connectivity (FC), the extent to which brain areas functionally interact. We studied FC networks in relation to language functioning in glioma and meningioma patients. Method: Patients with a low-grade glioma (N = 15) or meningioma (N = 10) infiltrating into/pressing on the language-dominant hemisphere underwent extensive language testing before and 1 year after surgery. Resting-state EEG was registered preoperatively, postoperatively (glioma patients only), and once in healthy individuals. After analyzing FC in theta and alpha frequency bands, weighted networks and Minimum Spanning Trees were quantified by various network measures. Results: Pre-operative FC network characteristics did not differ between glioma patients and healthy individuals. However, hub presence and higher local and global FC are associated with poorer language functioning before surgery in glioma patients and predict worse language performance at 1 year after surgery. For meningioma patients, a greater small worldness was related to worse language performance and hub presence; better average clustering and global integration were predictive of worse outcome on language function 1 year after surgery. The average eccentricity, diameter and tree hierarchy seem to be the network metrics with the more pronounced relation to language performance. Discussion: In this exploratory study, we demonstrated that preoperative FC networks are informative for pre- and postoperative language functioning in glioma patients and to a lesser extent in meningioma patients. Frontiers Media S.A. 2021-12-08 /pmc/articles/PMC8693574/ /pubmed/34955732 http://dx.doi.org/10.3389/fnins.2021.785969 Text en Copyright © 2021 Wolthuis, Satoer, Veenstra, Smits, Wagemakers, Vincent, Bastiaanse, Cherian and Bosma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wolthuis, Nienke
Satoer, Djaina
Veenstra, Wencke
Smits, Marion
Wagemakers, Michiel
Vincent, Arnaud
Bastiaanse, Roelien
Cherian, Perumpillichira J.
Bosma, Ingeborg
Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients
title Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients
title_full Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients
title_fullStr Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients
title_full_unstemmed Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients
title_short Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients
title_sort resting-state electroencephalography functional connectivity networks relate to pre- and postoperative language functioning in low-grade glioma and meningioma patients
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693574/
https://www.ncbi.nlm.nih.gov/pubmed/34955732
http://dx.doi.org/10.3389/fnins.2021.785969
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