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Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by the loss of motor neurons. We utilized single-cell transcriptomics to uncover dysfunctional pathways in degenerating motor neurons differentiated from SOD1 E100G ALS patient-derived induced pluripotent stem c...

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Detalles Bibliográficos
Autores principales:	Namboori, Seema C., Thomas, Patricia, Ames, Ryan, Hawkins, Sophie, Garrett, Lawrence O., Willis, Craig R.G., Rosa, Alessandro, Stanton, Lawrence W., Bhinge, Akshay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693652/ https://www.ncbi.nlm.nih.gov/pubmed/34767750 http://dx.doi.org/10.1016/j.stemcr.2021.10.010

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