Development of human iPSC-derived quiescent hepatic stellate cell-like cells for drug discovery and in vitro disease modeling

Hepatic stellate cells (HSCs) play a central role in the progression of liver fibrosis by producing extracellular matrices. The development of drugs to suppress liver fibrosis has been hampered by the lack of human quiescent HSCs (qHSCs) and an appropriate in vitro model that faithfully recapitulate...

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Detalles Bibliográficos
Autores principales: Koui, Yuta, Himeno, Misao, Mori, Yusuke, Nakano, Yasuhiro, Saijou, Eiko, Tanimizu, Naoki, Kamiya, Yoshiko, Anzai, Hiroko, Maeda, Natsuki, Wang, Luyao, Yamada, Tadanori, Sakai, Yasuyuki, Nakato, Ryuichiro, Miyajima, Atsushi, Kido, Taketomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693663/
https://www.ncbi.nlm.nih.gov/pubmed/34861166
http://dx.doi.org/10.1016/j.stemcr.2021.11.002

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