A mild one-pot synthesis of 2-iminothiazolines from thioureas and 1-bromo-1-nitroalkenes

A mild method to access functionalized 2-iminothiazolines in a facile and efficient manner has been developed. The reaction started from 1,3-disubstituted thioureas and 1-bromo-1-nitroalkenes in the presence of triethylamine in THF and proceeded smoothly in air to afford 2-iminothiazoline derivative...

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Detalles Bibliográficos
Autores principales: Xu, Yuan, Ge, Xin, Zhang, Yuhan, Zhang, Hongbin, Liu, Xue-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693722/
https://www.ncbi.nlm.nih.gov/pubmed/35424148
http://dx.doi.org/10.1039/d0ra00686f
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author Xu, Yuan
Ge, Xin
Zhang, Yuhan
Zhang, Hongbin
Liu, Xue-Wei
author_facet Xu, Yuan
Ge, Xin
Zhang, Yuhan
Zhang, Hongbin
Liu, Xue-Wei
author_sort Xu, Yuan
collection PubMed
description A mild method to access functionalized 2-iminothiazolines in a facile and efficient manner has been developed. The reaction started from 1,3-disubstituted thioureas and 1-bromo-1-nitroalkenes in the presence of triethylamine in THF and proceeded smoothly in air to afford 2-iminothiazoline derivatives in moderate to good yields.
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spelling pubmed-86937222022-04-13 A mild one-pot synthesis of 2-iminothiazolines from thioureas and 1-bromo-1-nitroalkenes Xu, Yuan Ge, Xin Zhang, Yuhan Zhang, Hongbin Liu, Xue-Wei RSC Adv Chemistry A mild method to access functionalized 2-iminothiazolines in a facile and efficient manner has been developed. The reaction started from 1,3-disubstituted thioureas and 1-bromo-1-nitroalkenes in the presence of triethylamine in THF and proceeded smoothly in air to afford 2-iminothiazoline derivatives in moderate to good yields. The Royal Society of Chemistry 2021-01-08 /pmc/articles/PMC8693722/ /pubmed/35424148 http://dx.doi.org/10.1039/d0ra00686f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Xu, Yuan
Ge, Xin
Zhang, Yuhan
Zhang, Hongbin
Liu, Xue-Wei
A mild one-pot synthesis of 2-iminothiazolines from thioureas and 1-bromo-1-nitroalkenes
title A mild one-pot synthesis of 2-iminothiazolines from thioureas and 1-bromo-1-nitroalkenes
title_full A mild one-pot synthesis of 2-iminothiazolines from thioureas and 1-bromo-1-nitroalkenes
title_fullStr A mild one-pot synthesis of 2-iminothiazolines from thioureas and 1-bromo-1-nitroalkenes
title_full_unstemmed A mild one-pot synthesis of 2-iminothiazolines from thioureas and 1-bromo-1-nitroalkenes
title_short A mild one-pot synthesis of 2-iminothiazolines from thioureas and 1-bromo-1-nitroalkenes
title_sort mild one-pot synthesis of 2-iminothiazolines from thioureas and 1-bromo-1-nitroalkenes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693722/
https://www.ncbi.nlm.nih.gov/pubmed/35424148
http://dx.doi.org/10.1039/d0ra00686f
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