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Prevalence and Risk Factors for Hepatitis C Virus Co-infection among Human Immunodeficiency Virus-Infected Patients and Effect of Hepatitis C Virus Infection on Acquired Immunodeficiency Syndrome Cases at Baseline
BACKGROUND: Hepatitis C virus (HCV) co-infection with human immunodeficiency virus (HIV) exists as both viruses have the common routes of transmission. HIV infection has adverse effect on the natural history of HCV infection; however, the effect of HCV infection on the natural history of HIV infecti...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693737/ https://www.ncbi.nlm.nih.gov/pubmed/34893569 http://dx.doi.org/10.4103/aam.aam_65_20 |
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author | Yakubu, Abdulmumini Hali, Bello Maiyaki, Abubakar Sadiq |
author_facet | Yakubu, Abdulmumini Hali, Bello Maiyaki, Abubakar Sadiq |
author_sort | Yakubu, Abdulmumini |
collection | PubMed |
description | BACKGROUND: Hepatitis C virus (HCV) co-infection with human immunodeficiency virus (HIV) exists as both viruses have the common routes of transmission. HIV infection has adverse effect on the natural history of HCV infection; however, the effect of HCV infection on the natural history of HIV infection is unclear. MATERIALS AND METHODS: This study was cross-sectional comprising of treatment-naïve adult HIV-infected patients attending clinics at Usmanu Danfodiyo University Teaching Hospital, Sokoto and Specialist Hospital Sokoto. The study participants were screened for HCV anti]body and assayed for transaminases and CD4(+) T-lymphocytes count levels. The symptoms of acquired immunodeficiency syndrome (AIDS)-defining illnesses were asked among the study participants. The questionnaire was used for the collection of data, and SPSS software version 20 was used for the analysis of data. Student's t-tests, Pearson’s, Chi-square, and Fisher's exact tests were used for the statistical analysis, and P < 0.05 was considered statistically significant. RESULTS: The prevalence of HIV/HCV co-infection was 20.6%. Self-intravenous drugs usage was not statistically significant (P = 0.210). HIV mono-infected patients had significantly lower alanine aminotransferase levels compared to HIV/HCV co-infected study participants (P = 0.048). AIDS status at the baseline was comparable between HIV mono-infected and HIV/HCV co-infected study participants. (P = 0.227; 0.200; 0.130). CONCLUSION: Moderately high prevalence of HIV/HCV co-infection was observed in the current study. HCV co-infection had no effect on AIDS status at baseline. There is a need for routine screening of HCV infection in HIV-infected individuals. |
format | Online Article Text |
id | pubmed-8693737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-86937372022-01-10 Prevalence and Risk Factors for Hepatitis C Virus Co-infection among Human Immunodeficiency Virus-Infected Patients and Effect of Hepatitis C Virus Infection on Acquired Immunodeficiency Syndrome Cases at Baseline Yakubu, Abdulmumini Hali, Bello Maiyaki, Abubakar Sadiq Ann Afr Med Original Article BACKGROUND: Hepatitis C virus (HCV) co-infection with human immunodeficiency virus (HIV) exists as both viruses have the common routes of transmission. HIV infection has adverse effect on the natural history of HCV infection; however, the effect of HCV infection on the natural history of HIV infection is unclear. MATERIALS AND METHODS: This study was cross-sectional comprising of treatment-naïve adult HIV-infected patients attending clinics at Usmanu Danfodiyo University Teaching Hospital, Sokoto and Specialist Hospital Sokoto. The study participants were screened for HCV anti]body and assayed for transaminases and CD4(+) T-lymphocytes count levels. The symptoms of acquired immunodeficiency syndrome (AIDS)-defining illnesses were asked among the study participants. The questionnaire was used for the collection of data, and SPSS software version 20 was used for the analysis of data. Student's t-tests, Pearson’s, Chi-square, and Fisher's exact tests were used for the statistical analysis, and P < 0.05 was considered statistically significant. RESULTS: The prevalence of HIV/HCV co-infection was 20.6%. Self-intravenous drugs usage was not statistically significant (P = 0.210). HIV mono-infected patients had significantly lower alanine aminotransferase levels compared to HIV/HCV co-infected study participants (P = 0.048). AIDS status at the baseline was comparable between HIV mono-infected and HIV/HCV co-infected study participants. (P = 0.227; 0.200; 0.130). CONCLUSION: Moderately high prevalence of HIV/HCV co-infection was observed in the current study. HCV co-infection had no effect on AIDS status at baseline. There is a need for routine screening of HCV infection in HIV-infected individuals. Wolters Kluwer - Medknow 2021 2021-12-03 /pmc/articles/PMC8693737/ /pubmed/34893569 http://dx.doi.org/10.4103/aam.aam_65_20 Text en Copyright: © 2021 Annals of African Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Yakubu, Abdulmumini Hali, Bello Maiyaki, Abubakar Sadiq Prevalence and Risk Factors for Hepatitis C Virus Co-infection among Human Immunodeficiency Virus-Infected Patients and Effect of Hepatitis C Virus Infection on Acquired Immunodeficiency Syndrome Cases at Baseline |
title | Prevalence and Risk Factors for Hepatitis C Virus Co-infection among Human Immunodeficiency Virus-Infected Patients and Effect of Hepatitis C Virus Infection on Acquired Immunodeficiency Syndrome Cases at Baseline |
title_full | Prevalence and Risk Factors for Hepatitis C Virus Co-infection among Human Immunodeficiency Virus-Infected Patients and Effect of Hepatitis C Virus Infection on Acquired Immunodeficiency Syndrome Cases at Baseline |
title_fullStr | Prevalence and Risk Factors for Hepatitis C Virus Co-infection among Human Immunodeficiency Virus-Infected Patients and Effect of Hepatitis C Virus Infection on Acquired Immunodeficiency Syndrome Cases at Baseline |
title_full_unstemmed | Prevalence and Risk Factors for Hepatitis C Virus Co-infection among Human Immunodeficiency Virus-Infected Patients and Effect of Hepatitis C Virus Infection on Acquired Immunodeficiency Syndrome Cases at Baseline |
title_short | Prevalence and Risk Factors for Hepatitis C Virus Co-infection among Human Immunodeficiency Virus-Infected Patients and Effect of Hepatitis C Virus Infection on Acquired Immunodeficiency Syndrome Cases at Baseline |
title_sort | prevalence and risk factors for hepatitis c virus co-infection among human immunodeficiency virus-infected patients and effect of hepatitis c virus infection on acquired immunodeficiency syndrome cases at baseline |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693737/ https://www.ncbi.nlm.nih.gov/pubmed/34893569 http://dx.doi.org/10.4103/aam.aam_65_20 |
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