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Frequency of pyrethroid resistance in human head louse treatment: systematic review and meta-analysis

Head lice (Pediculus humanus capitis) are one of the most common insects causing infestations in humans worldwide, and infestation is associated with adverse socio-economic and public health effects. The development of genetic insensitivity (e.g., target site insensitivity = knockdown resistance or...

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Autores principales: Mohammadi, Jalal, Azizi, Kourosh, Alipour, Hamzeh, Kalantari, Mohsen, Bagheri, Masoumeh, Shahriari-Namadi, Marzieh, Ebrahimi, Saeedeh, Moemenbellah-Fard, Mohammad D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: EDP Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693761/
https://www.ncbi.nlm.nih.gov/pubmed/34935614
http://dx.doi.org/10.1051/parasite/2021083
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author Mohammadi, Jalal
Azizi, Kourosh
Alipour, Hamzeh
Kalantari, Mohsen
Bagheri, Masoumeh
Shahriari-Namadi, Marzieh
Ebrahimi, Saeedeh
Moemenbellah-Fard, Mohammad D.
author_facet Mohammadi, Jalal
Azizi, Kourosh
Alipour, Hamzeh
Kalantari, Mohsen
Bagheri, Masoumeh
Shahriari-Namadi, Marzieh
Ebrahimi, Saeedeh
Moemenbellah-Fard, Mohammad D.
author_sort Mohammadi, Jalal
collection PubMed
description Head lice (Pediculus humanus capitis) are one of the most common insects causing infestations in humans worldwide, and infestation is associated with adverse socio-economic and public health effects. The development of genetic insensitivity (e.g., target site insensitivity = knockdown resistance or kdr) to topical insecticides has impaired effective treatment. Therefore, this study was undertaken to review and meta-analyze the frequency of pyrethroid resistance in treated head louse populations from the beginning of 2000 to the end of June 2021 worldwide. In order to accomplish this, all English language articles published over this period were extracted and reviewed. Statistical analyses of data were performed using fixed and random effect model tests in meta-analysis, Cochrane, meta-regression and I2 index. A total of 24 articles from an initial sample size of 5033 were accepted into this systematic review. The mean frequency of pyrethroid resistance was estimated to be 76.9%. In collected resistant lice, 64.4% were homozygote and 30.3% were heterozygote resistant. Globally, four countries (Australia, England, Israel, and Turkey) have 100% kdr gene frequencies, likely resulting in the ineffectiveness of pyrethrin- and pyrethroid-based pediculicides. The highest resistance recorded in these studies was against permethrin. This study shows that pyrethroid resistance is found at relatively high frequencies in many countries. As a result, treatment with current insecticides may not be effective and is likely the cause of increased levels of infestations. It is recommended that resistance status be evaluated prior to insecticide treatment, to increase efficacy.
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spelling pubmed-86937612022-01-11 Frequency of pyrethroid resistance in human head louse treatment: systematic review and meta-analysis Mohammadi, Jalal Azizi, Kourosh Alipour, Hamzeh Kalantari, Mohsen Bagheri, Masoumeh Shahriari-Namadi, Marzieh Ebrahimi, Saeedeh Moemenbellah-Fard, Mohammad D. Parasite Review Article Head lice (Pediculus humanus capitis) are one of the most common insects causing infestations in humans worldwide, and infestation is associated with adverse socio-economic and public health effects. The development of genetic insensitivity (e.g., target site insensitivity = knockdown resistance or kdr) to topical insecticides has impaired effective treatment. Therefore, this study was undertaken to review and meta-analyze the frequency of pyrethroid resistance in treated head louse populations from the beginning of 2000 to the end of June 2021 worldwide. In order to accomplish this, all English language articles published over this period were extracted and reviewed. Statistical analyses of data were performed using fixed and random effect model tests in meta-analysis, Cochrane, meta-regression and I2 index. A total of 24 articles from an initial sample size of 5033 were accepted into this systematic review. The mean frequency of pyrethroid resistance was estimated to be 76.9%. In collected resistant lice, 64.4% were homozygote and 30.3% were heterozygote resistant. Globally, four countries (Australia, England, Israel, and Turkey) have 100% kdr gene frequencies, likely resulting in the ineffectiveness of pyrethrin- and pyrethroid-based pediculicides. The highest resistance recorded in these studies was against permethrin. This study shows that pyrethroid resistance is found at relatively high frequencies in many countries. As a result, treatment with current insecticides may not be effective and is likely the cause of increased levels of infestations. It is recommended that resistance status be evaluated prior to insecticide treatment, to increase efficacy. EDP Sciences 2021-12-22 /pmc/articles/PMC8693761/ /pubmed/34935614 http://dx.doi.org/10.1051/parasite/2021083 Text en © J. Mohammadi et al., published by EDP Sciences, 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mohammadi, Jalal
Azizi, Kourosh
Alipour, Hamzeh
Kalantari, Mohsen
Bagheri, Masoumeh
Shahriari-Namadi, Marzieh
Ebrahimi, Saeedeh
Moemenbellah-Fard, Mohammad D.
Frequency of pyrethroid resistance in human head louse treatment: systematic review and meta-analysis
title Frequency of pyrethroid resistance in human head louse treatment: systematic review and meta-analysis
title_full Frequency of pyrethroid resistance in human head louse treatment: systematic review and meta-analysis
title_fullStr Frequency of pyrethroid resistance in human head louse treatment: systematic review and meta-analysis
title_full_unstemmed Frequency of pyrethroid resistance in human head louse treatment: systematic review and meta-analysis
title_short Frequency of pyrethroid resistance in human head louse treatment: systematic review and meta-analysis
title_sort frequency of pyrethroid resistance in human head louse treatment: systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693761/
https://www.ncbi.nlm.nih.gov/pubmed/34935614
http://dx.doi.org/10.1051/parasite/2021083
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