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Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles

Arenesulfonyl indoles, bearing a good leaving group, are effective precursors for vinylogous imine intermediates which are generated in situ under basic conditions. This intermediate can readily react with other nucleophilic reagents to obtain C-3 substituted indole derivatives. In the last few year...

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Detalles Bibliográficos
Autores principales: Kaur, Banni Preet, Kaur, Jasneet, Chimni, Swapandeep Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693840/
https://www.ncbi.nlm.nih.gov/pubmed/35424187
http://dx.doi.org/10.1039/d0ra09133b
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author Kaur, Banni Preet
Kaur, Jasneet
Chimni, Swapandeep Singh
author_facet Kaur, Banni Preet
Kaur, Jasneet
Chimni, Swapandeep Singh
author_sort Kaur, Banni Preet
collection PubMed
description Arenesulfonyl indoles, bearing a good leaving group, are effective precursors for vinylogous imine intermediates which are generated in situ under basic conditions. This intermediate can readily react with other nucleophilic reagents to obtain C-3 substituted indole derivatives. In the last few years, a plethora of exciting synthetic applications of this substrate have been exploited. The stability of arylsulfonyl-containing substrates, mild reaction conditions, and the large variety of nucleophiles involved in these procedures are the key to their success in organic synthesis.
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spelling pubmed-86938402022-04-13 Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles Kaur, Banni Preet Kaur, Jasneet Chimni, Swapandeep Singh RSC Adv Chemistry Arenesulfonyl indoles, bearing a good leaving group, are effective precursors for vinylogous imine intermediates which are generated in situ under basic conditions. This intermediate can readily react with other nucleophilic reagents to obtain C-3 substituted indole derivatives. In the last few years, a plethora of exciting synthetic applications of this substrate have been exploited. The stability of arylsulfonyl-containing substrates, mild reaction conditions, and the large variety of nucleophiles involved in these procedures are the key to their success in organic synthesis. The Royal Society of Chemistry 2021-01-08 /pmc/articles/PMC8693840/ /pubmed/35424187 http://dx.doi.org/10.1039/d0ra09133b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Kaur, Banni Preet
Kaur, Jasneet
Chimni, Swapandeep Singh
Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles
title Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles
title_full Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles
title_fullStr Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles
title_full_unstemmed Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles
title_short Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles
title_sort arenesulfonyl indole: new precursor for diversification of c-3 functionalized indoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693840/
https://www.ncbi.nlm.nih.gov/pubmed/35424187
http://dx.doi.org/10.1039/d0ra09133b
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