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Chemical strategies for strand selection in short-interfering RNAs

Therapeutic small interfering RNAs (siRNAs) are double stranded RNAs capable of potent and specific gene silencing through activation of the RNA interference (RNAi) pathway. The potential of siRNA drugs has recently been highlighted by the approval of multiple siRNA therapeutics. These successes rel...

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Detalles Bibliográficos
Autores principales:	Varley, Andrew J., Desaulniers, Jean-Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693850/ https://www.ncbi.nlm.nih.gov/pubmed/35424193 http://dx.doi.org/10.1039/d0ra07747j

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