Structure, mechanism, and inhibition of Hedgehog acyltransferase

The Sonic Hedgehog (SHH) morphogen pathway is fundamental for embryonic development and stem cell maintenance and is implicated in various cancers. A key step in signaling is transfer of a palmitate group to the SHH N terminus, catalyzed by the multi-pass transmembrane enzyme Hedgehog acyltransferas...

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Detalles Bibliográficos
Autores principales: Coupland, Claire E., Andrei, Sebastian A., Ansell, T. Bertie, Carrique, Loic, Kumar, Pramod, Sefer, Lea, Schwab, Rebekka A., Byrne, Eamon F.X., Pardon, Els, Steyaert, Jan, Magee, Anthony I., Lanyon-Hogg, Thomas, Sansom, Mark S.P., Tate, Edward W., Siebold, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693861/
https://www.ncbi.nlm.nih.gov/pubmed/34890564
http://dx.doi.org/10.1016/j.molcel.2021.11.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693861/
https://www.ncbi.nlm.nih.gov/pubmed/34890564
http://dx.doi.org/10.1016/j.molcel.2021.11.018

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