ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion

Myoblast fusion is essential for muscle development and regeneration. Yet, it remains poorly understood how mononucleated myoblasts fuse with preexisting fibers. We demonstrate that ERK1/2 inhibition (ERKi) induces robust differentiation and fusion of primary mouse myoblasts through a linear pathway...

Descripción completa

Detalles Bibliográficos
Autores principales: Eigler, Tamar, Zarfati, Giulia, Amzallag, Emmanuel, Sinha, Sansrity, Segev, Nadav, Zabary, Yishaia, Zaritsky, Assaf, Shakked, Avraham, Umansky, Kfir-Baruch, Schejter, Eyal D., Millay, Douglas P., Tzahor, Eldad, Avinoam, Ori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693863/
https://www.ncbi.nlm.nih.gov/pubmed/34932950
http://dx.doi.org/10.1016/j.devcel.2021.11.022

Ejemplares similares

Ejemplares similares