Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6

Two new xanthones, oxisterigmatocystins J and K (1–2), and two new anthraquinones, versicolorins D and E (3–4), were isolated from solid cultures of the fungus Penicillium sp. DWS10-P-6, together with twelve known compounds (5–16). Their structures, including their absolute configurations, were char...

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Detalles Bibliográficos
Autores principales: Wang, Ya-jing, Ma, Nan, Liu, Chun-yue, Feng, Yi-xuan, Zhang, Feng-xiang, Li, Chang, Pei, Yue-hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693886/
https://www.ncbi.nlm.nih.gov/pubmed/35424208
http://dx.doi.org/10.1039/d0ra08141h
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author Wang, Ya-jing
Ma, Nan
Liu, Chun-yue
Feng, Yi-xuan
Zhang, Feng-xiang
Li, Chang
Pei, Yue-hu
author_facet Wang, Ya-jing
Ma, Nan
Liu, Chun-yue
Feng, Yi-xuan
Zhang, Feng-xiang
Li, Chang
Pei, Yue-hu
author_sort Wang, Ya-jing
collection PubMed
description Two new xanthones, oxisterigmatocystins J and K (1–2), and two new anthraquinones, versicolorins D and E (3–4), were isolated from solid cultures of the fungus Penicillium sp. DWS10-P-6, together with twelve known compounds (5–16). Their structures, including their absolute configurations, were characterized on the basis of extensive 1D NMR, 2D NMR, MS and CD spectral data. The cytotoxic activities of compounds 1–12 against HL-60, MDA-MB-231 and PC-3 cells were also evaluated. Compounds 4 and 5 showed significant cytotoxic activity against the HL-60 cell line with IC(50) values of 1.65 μM and 1.05 μM, respectively.
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spelling pubmed-86938862022-04-13 Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6 Wang, Ya-jing Ma, Nan Liu, Chun-yue Feng, Yi-xuan Zhang, Feng-xiang Li, Chang Pei, Yue-hu RSC Adv Chemistry Two new xanthones, oxisterigmatocystins J and K (1–2), and two new anthraquinones, versicolorins D and E (3–4), were isolated from solid cultures of the fungus Penicillium sp. DWS10-P-6, together with twelve known compounds (5–16). Their structures, including their absolute configurations, were characterized on the basis of extensive 1D NMR, 2D NMR, MS and CD spectral data. The cytotoxic activities of compounds 1–12 against HL-60, MDA-MB-231 and PC-3 cells were also evaluated. Compounds 4 and 5 showed significant cytotoxic activity against the HL-60 cell line with IC(50) values of 1.65 μM and 1.05 μM, respectively. The Royal Society of Chemistry 2021-01-14 /pmc/articles/PMC8693886/ /pubmed/35424208 http://dx.doi.org/10.1039/d0ra08141h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Wang, Ya-jing
Ma, Nan
Liu, Chun-yue
Feng, Yi-xuan
Zhang, Feng-xiang
Li, Chang
Pei, Yue-hu
Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6
title Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6
title_full Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6
title_fullStr Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6
title_full_unstemmed Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6
title_short Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6
title_sort xanthones and anthraquinones from the soil fungus penicillium sp. dws10-p-6
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693886/
https://www.ncbi.nlm.nih.gov/pubmed/35424208
http://dx.doi.org/10.1039/d0ra08141h
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