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Reverted HIV-1 Mutants in CD4(+) T-Cells Reveal Critical Residues in the Polar Region of Viral Envelope Glycoprotein

HIV-1 envelope glycoprotein (Env) interacts with cell surface receptors and induces membrane fusion to enter cells and initiate infection. HIV-1 Env on virions comprises trimers of the gp120 and gp41 subunits. The polar region (PR) in the N-terminus of gp41 is composed of 17 conserved residues, incl...

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Detalles Bibliográficos
Autores principales:	Lu, Wuxun, Li, Tai-Wei, Phillips, Stacia, Wu, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Observation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693918/ https://www.ncbi.nlm.nih.gov/pubmed/34935422 http://dx.doi.org/10.1128/spectrum.01653-21

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