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Alcohol functionality in the fatty acid backbone of sphingomyelin guides the inhibition of blood coagulation
Cell-surface sphingomyelin (SM) inhibits binary and ternary complex activity of blood coagulation by an unknown mechanism. Here we show the OH functionality of SM contributes in forming the close assembly through intermolecular H-bond and through Ca(2+) chelation, which restricts the protein–lipid/p...
Autores principales: | Mallik, S., Prasad, R., Das, K., Sen, P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694017/ https://www.ncbi.nlm.nih.gov/pubmed/35424312 http://dx.doi.org/10.1039/d0ra09218e |
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