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Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family
We show that salacinol-type α-glucosidase inhibitors are ligand-compatible with the GH 31 family. Salacinol and its 3′-O-benzylated analogs inhibit human lysosomal α-glucosidase at submicromolar levels. Simple structure-activity relationship studies reveal that the salacinol side-chain stereochemist...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694024/ https://www.ncbi.nlm.nih.gov/pubmed/35424309 http://dx.doi.org/10.1039/d0ra10038b |
| _version_ | 1784619263369150464 |
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| author | Ishikawa, Fumihiro Hirano, Aiko Yoshimori, Yuuto Nishida, Kana Nakamura, Shinya Takashima, Katsuki Marumoto, Shinsuke Ninomiya, Kiyofumi Nakanishi, Isao Xie, Weijia Morikawa, Toshio Muraoka, Osamu Tanabe, Genzoh |
| author_facet | Ishikawa, Fumihiro Hirano, Aiko Yoshimori, Yuuto Nishida, Kana Nakamura, Shinya Takashima, Katsuki Marumoto, Shinsuke Ninomiya, Kiyofumi Nakanishi, Isao Xie, Weijia Morikawa, Toshio Muraoka, Osamu Tanabe, Genzoh |
| author_sort | Ishikawa, Fumihiro |
| collection | PubMed |
| description | We show that salacinol-type α-glucosidase inhibitors are ligand-compatible with the GH 31 family. Salacinol and its 3′-O-benzylated analogs inhibit human lysosomal α-glucosidase at submicromolar levels. Simple structure-activity relationship studies reveal that the salacinol side-chain stereochemistry significantly influences binding to GH31 α-glucosidases. |
| format | Online Article Text |
| id | pubmed-8694024 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | The Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86940242022-04-13 Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family Ishikawa, Fumihiro Hirano, Aiko Yoshimori, Yuuto Nishida, Kana Nakamura, Shinya Takashima, Katsuki Marumoto, Shinsuke Ninomiya, Kiyofumi Nakanishi, Isao Xie, Weijia Morikawa, Toshio Muraoka, Osamu Tanabe, Genzoh RSC Adv Chemistry We show that salacinol-type α-glucosidase inhibitors are ligand-compatible with the GH 31 family. Salacinol and its 3′-O-benzylated analogs inhibit human lysosomal α-glucosidase at submicromolar levels. Simple structure-activity relationship studies reveal that the salacinol side-chain stereochemistry significantly influences binding to GH31 α-glucosidases. The Royal Society of Chemistry 2021-01-15 /pmc/articles/PMC8694024/ /pubmed/35424309 http://dx.doi.org/10.1039/d0ra10038b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
| spellingShingle | Chemistry Ishikawa, Fumihiro Hirano, Aiko Yoshimori, Yuuto Nishida, Kana Nakamura, Shinya Takashima, Katsuki Marumoto, Shinsuke Ninomiya, Kiyofumi Nakanishi, Isao Xie, Weijia Morikawa, Toshio Muraoka, Osamu Tanabe, Genzoh Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family |
| title | Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family |
| title_full | Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family |
| title_fullStr | Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family |
| title_full_unstemmed | Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family |
| title_short | Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family |
| title_sort | ligand compatibility of salacinol-type α-glucosidase inhibitors toward the gh31 family |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694024/ https://www.ncbi.nlm.nih.gov/pubmed/35424309 http://dx.doi.org/10.1039/d0ra10038b |
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