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Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family

We show that salacinol-type α-glucosidase inhibitors are ligand-compatible with the GH 31 family. Salacinol and its 3′-O-benzylated analogs inhibit human lysosomal α-glucosidase at submicromolar levels. Simple structure-activity relationship studies reveal that the salacinol side-chain stereochemist...

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Detalles Bibliográficos
Autores principales:	Ishikawa, Fumihiro, Hirano, Aiko, Yoshimori, Yuuto, Nishida, Kana, Nakamura, Shinya, Takashima, Katsuki, Marumoto, Shinsuke, Ninomiya, Kiyofumi, Nakanishi, Isao, Xie, Weijia, Morikawa, Toshio, Muraoka, Osamu, Tanabe, Genzoh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694024/ https://www.ncbi.nlm.nih.gov/pubmed/35424309 http://dx.doi.org/10.1039/d0ra10038b

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