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Point-of-Care Capillary Blood Creatinine: A Prospective study in Cardiology and Nephrology Outpatients

BACKGROUND: The radiological or interventional use of contrast medium exposes patients to a risk of contrast-induced nephropathy. Pre-existing kidney failure is a major risk factor. Point-of-Care Capillary blood creatinine tests are promising; their speed might help to optimize treatment decisions a...

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Autores principales: Vilaine, Eve, Gabarre, Paul, Beauchet, Alain, Seidowsky, Alexandre, Auzel, Olivier, Hauguel-Moreau, Marie, Dubourg, Olivier, Mansencal, Nicolas, Essig, Marie, Massy, Ziad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694036/
https://www.ncbi.nlm.nih.gov/pubmed/34950855
http://dx.doi.org/10.26502/fccm.92920229
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author Vilaine, Eve
Gabarre, Paul
Beauchet, Alain
Seidowsky, Alexandre
Auzel, Olivier
Hauguel-Moreau, Marie
Dubourg, Olivier
Mansencal, Nicolas
Essig, Marie
Massy, Ziad A.
author_facet Vilaine, Eve
Gabarre, Paul
Beauchet, Alain
Seidowsky, Alexandre
Auzel, Olivier
Hauguel-Moreau, Marie
Dubourg, Olivier
Mansencal, Nicolas
Essig, Marie
Massy, Ziad A.
author_sort Vilaine, Eve
collection PubMed
description BACKGROUND: The radiological or interventional use of contrast medium exposes patients to a risk of contrast-induced nephropathy. Pre-existing kidney failure is a major risk factor. Point-of-Care Capillary blood creatinine tests are promising; their speed might help to optimize treatment decisions and patient care in these situations. METHODS: The objective of the present study was to assess the ability of a new point of care capillary blood creatinine test (Stat Sensor X-press, Nova Biomedical Cooperation, Waltham, MA, USA) to diagnose kidney failure, relative to a standard lab-based plasma creatinine assay. A total of 113 patients 33 women (29.2%) were included. The capillary blood creatinine concentration was significantly correlated with the plasma creatinine concentration in both men (Pearson’s r [95% Confidence Interval (CI)] = 0.84 [0.75 – 0.89]; p<0.001) and women (Pearson’s r [95%CI] = 0.95 [0.89 – 0.97]; p<0.001). The test’s diagnostic performance was satisfactory, its sensitivity was 70% [35 – 93] in women and 78% [52 – 94] in men, and its specificity was 91% [72 – 99] in woman and 93% [84 – 98] in men. CONCLUSION: Rapid Point-of Care Capillary creatinine test is an easy-to-use, accurate tool for detecting kidney failure before a patient is exposed to procedures involving contrast medium. The POC test performed less well in patients over the age of 75 and in patients with high plasma creatinine level
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spelling pubmed-86940362021-12-22 Point-of-Care Capillary Blood Creatinine: A Prospective study in Cardiology and Nephrology Outpatients Vilaine, Eve Gabarre, Paul Beauchet, Alain Seidowsky, Alexandre Auzel, Olivier Hauguel-Moreau, Marie Dubourg, Olivier Mansencal, Nicolas Essig, Marie Massy, Ziad A. Cardiol Cardiovasc Med Article BACKGROUND: The radiological or interventional use of contrast medium exposes patients to a risk of contrast-induced nephropathy. Pre-existing kidney failure is a major risk factor. Point-of-Care Capillary blood creatinine tests are promising; their speed might help to optimize treatment decisions and patient care in these situations. METHODS: The objective of the present study was to assess the ability of a new point of care capillary blood creatinine test (Stat Sensor X-press, Nova Biomedical Cooperation, Waltham, MA, USA) to diagnose kidney failure, relative to a standard lab-based plasma creatinine assay. A total of 113 patients 33 women (29.2%) were included. The capillary blood creatinine concentration was significantly correlated with the plasma creatinine concentration in both men (Pearson’s r [95% Confidence Interval (CI)] = 0.84 [0.75 – 0.89]; p<0.001) and women (Pearson’s r [95%CI] = 0.95 [0.89 – 0.97]; p<0.001). The test’s diagnostic performance was satisfactory, its sensitivity was 70% [35 – 93] in women and 78% [52 – 94] in men, and its specificity was 91% [72 – 99] in woman and 93% [84 – 98] in men. CONCLUSION: Rapid Point-of Care Capillary creatinine test is an easy-to-use, accurate tool for detecting kidney failure before a patient is exposed to procedures involving contrast medium. The POC test performed less well in patients over the age of 75 and in patients with high plasma creatinine level 2021 2021-12-03 /pmc/articles/PMC8694036/ /pubmed/34950855 http://dx.doi.org/10.26502/fccm.92920229 Text en https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license 4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Vilaine, Eve
Gabarre, Paul
Beauchet, Alain
Seidowsky, Alexandre
Auzel, Olivier
Hauguel-Moreau, Marie
Dubourg, Olivier
Mansencal, Nicolas
Essig, Marie
Massy, Ziad A.
Point-of-Care Capillary Blood Creatinine: A Prospective study in Cardiology and Nephrology Outpatients
title Point-of-Care Capillary Blood Creatinine: A Prospective study in Cardiology and Nephrology Outpatients
title_full Point-of-Care Capillary Blood Creatinine: A Prospective study in Cardiology and Nephrology Outpatients
title_fullStr Point-of-Care Capillary Blood Creatinine: A Prospective study in Cardiology and Nephrology Outpatients
title_full_unstemmed Point-of-Care Capillary Blood Creatinine: A Prospective study in Cardiology and Nephrology Outpatients
title_short Point-of-Care Capillary Blood Creatinine: A Prospective study in Cardiology and Nephrology Outpatients
title_sort point-of-care capillary blood creatinine: a prospective study in cardiology and nephrology outpatients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694036/
https://www.ncbi.nlm.nih.gov/pubmed/34950855
http://dx.doi.org/10.26502/fccm.92920229
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