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Neural circuit function redundancy in brain disorders
Redundancy is a ubiquitous property of the nervous system. This means that vastly different configurations of cellular and synaptic components can enable the same neural circuit functions. However, until recently, very little brain disorder research has considered the implications of this characteri...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Current Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694099/ https://www.ncbi.nlm.nih.gov/pubmed/34416675 http://dx.doi.org/10.1016/j.conb.2021.07.008 |
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author | Mizusaki, Beatriz E.P. O'Donnell, Cian |
author_facet | Mizusaki, Beatriz E.P. O'Donnell, Cian |
author_sort | Mizusaki, Beatriz E.P. |
collection | PubMed |
description | Redundancy is a ubiquitous property of the nervous system. This means that vastly different configurations of cellular and synaptic components can enable the same neural circuit functions. However, until recently, very little brain disorder research has considered the implications of this characteristic when designing experiments or interpreting data. Here, we first summarise the evidence for redundancy in healthy brains, explaining redundancy and three related sub-concepts: sloppiness, dependencies and multiple solutions. We then lay out key implications for brain disorder research, covering recent examples of redundancy effects in experimental studies on psychiatric disorders. Finally, we give predictions for future experiments based on these concepts. |
format | Online Article Text |
id | pubmed-8694099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Current Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-86940992022-01-04 Neural circuit function redundancy in brain disorders Mizusaki, Beatriz E.P. O'Donnell, Cian Curr Opin Neurobiol Article Redundancy is a ubiquitous property of the nervous system. This means that vastly different configurations of cellular and synaptic components can enable the same neural circuit functions. However, until recently, very little brain disorder research has considered the implications of this characteristic when designing experiments or interpreting data. Here, we first summarise the evidence for redundancy in healthy brains, explaining redundancy and three related sub-concepts: sloppiness, dependencies and multiple solutions. We then lay out key implications for brain disorder research, covering recent examples of redundancy effects in experimental studies on psychiatric disorders. Finally, we give predictions for future experiments based on these concepts. Current Biology 2021-10 /pmc/articles/PMC8694099/ /pubmed/34416675 http://dx.doi.org/10.1016/j.conb.2021.07.008 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mizusaki, Beatriz E.P. O'Donnell, Cian Neural circuit function redundancy in brain disorders |
title | Neural circuit function redundancy in brain disorders |
title_full | Neural circuit function redundancy in brain disorders |
title_fullStr | Neural circuit function redundancy in brain disorders |
title_full_unstemmed | Neural circuit function redundancy in brain disorders |
title_short | Neural circuit function redundancy in brain disorders |
title_sort | neural circuit function redundancy in brain disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694099/ https://www.ncbi.nlm.nih.gov/pubmed/34416675 http://dx.doi.org/10.1016/j.conb.2021.07.008 |
work_keys_str_mv | AT mizusakibeatrizep neuralcircuitfunctionredundancyinbraindisorders AT odonnellcian neuralcircuitfunctionredundancyinbraindisorders |