Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support

In recent years, preparation of fully protected trinucleotide phosphoramidites as synthons for the codon-based synthesis of gene libraries as well as for the assembly of oligonucleotides from blockmers has gained much attention. We here describe the preparation of such trinucleotide synthons on a so...

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Autores principales: Suchsland, Ruth, Appel, Bettina, Virta, Pasi, Müller, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694130/
https://www.ncbi.nlm.nih.gov/pubmed/35424330
http://dx.doi.org/10.1039/d0ra10941j
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author Suchsland, Ruth
Appel, Bettina
Virta, Pasi
Müller, Sabine
author_facet Suchsland, Ruth
Appel, Bettina
Virta, Pasi
Müller, Sabine
author_sort Suchsland, Ruth
collection PubMed
description In recent years, preparation of fully protected trinucleotide phosphoramidites as synthons for the codon-based synthesis of gene libraries as well as for the assembly of oligonucleotides from blockmers has gained much attention. We here describe the preparation of such trinucleotide synthons on a soluble support using a disulphide linker.
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spelling pubmed-86941302022-04-13 Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support Suchsland, Ruth Appel, Bettina Virta, Pasi Müller, Sabine RSC Adv Chemistry In recent years, preparation of fully protected trinucleotide phosphoramidites as synthons for the codon-based synthesis of gene libraries as well as for the assembly of oligonucleotides from blockmers has gained much attention. We here describe the preparation of such trinucleotide synthons on a soluble support using a disulphide linker. The Royal Society of Chemistry 2021-01-20 /pmc/articles/PMC8694130/ /pubmed/35424330 http://dx.doi.org/10.1039/d0ra10941j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Suchsland, Ruth
Appel, Bettina
Virta, Pasi
Müller, Sabine
Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support
title Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support
title_full Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support
title_fullStr Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support
title_full_unstemmed Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support
title_short Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support
title_sort synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694130/
https://www.ncbi.nlm.nih.gov/pubmed/35424330
http://dx.doi.org/10.1039/d0ra10941j
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