Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis

Two of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially limited to the role of hypoxia and sterol-stress-induced transc...

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Detalles Bibliográficos
Autores principales: Ollinger, Tomye L., Vu, Bao, Murante, Daniel, Parker, Josie E., Simonicova, Lucia, Doorley, Laura, Stamnes, Mark A., Kelly, Steven L., Rogers, P. David, Moye-Rowley, W. Scott, Krysan, Damian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694151/
https://www.ncbi.nlm.nih.gov/pubmed/34935446
http://dx.doi.org/10.1128/msphere.00830-21

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