Mutasynthetic Production and Antimicrobial Characterization of Darobactin Analogs

There is great need for therapeutics against multidrug-resistant, Gram-negative bacterial pathogens. Recently, darobactin A, a novel bicyclic heptapeptide that selectively kills Gram-negative bacteria by targeting the outer membrane protein BamA, was discovered. Its efficacy was proven in animal inf...

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Detalles Bibliográficos
Autores principales: Böhringer, Nils, Green, Robert, Liu, Yang, Mettal, Ute, Marner, Michael, Modaresi, Seyed Majed, Jakob, Roman P., Wuisan, Zerlina G., Maier, Timm, Iinishi, Akira, Hiller, Sebastian, Lewis, Kim, Schäberle, Till F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694152/
https://www.ncbi.nlm.nih.gov/pubmed/34937193
http://dx.doi.org/10.1128/spectrum.01535-21

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