Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb

Six undescribed polyketides, 1–6, were discovered from the fruits of Knema globularia (Lam.) warb. Two known polyketides and three known lignans were also isolated. Cytotoxicities against HepG2 and KKU-M156 cells of all polyketides were evaluated. Compound 1 displayed the most cytotoxic activity aga...

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Detalles Bibliográficos
Autores principales: Chuenban, Chindawadee, Sombatsri, Aonnicha, Sribuhom, Thurdpong, Pornchoo, Chanakan, Prawan, Auemduan, Tontapha, Sarawut, Amornkitbamrung, Vittaya, Yenjai, Chavi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694366/
https://www.ncbi.nlm.nih.gov/pubmed/35424356
http://dx.doi.org/10.1039/d0ra10498a
Descripción
Sumario:Six undescribed polyketides, 1–6, were discovered from the fruits of Knema globularia (Lam.) warb. Two known polyketides and three known lignans were also isolated. Cytotoxicities against HepG2 and KKU-M156 cells of all polyketides were evaluated. Compound 1 displayed the most cytotoxic activity against HepG2 and KKU-M156 cell lines with IC(50) values of 1.57 ± 0.37 and 1.78 ± 0.14 μg mL(−1), respectively. The structure of all isolates was identified using spectroscopic methods including NMR, IR, MS and ECD.

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