Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb

Six undescribed polyketides, 1–6, were discovered from the fruits of Knema globularia (Lam.) warb. Two known polyketides and three known lignans were also isolated. Cytotoxicities against HepG2 and KKU-M156 cells of all polyketides were evaluated. Compound 1 displayed the most cytotoxic activity aga...

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Autores principales: Chuenban, Chindawadee, Sombatsri, Aonnicha, Sribuhom, Thurdpong, Pornchoo, Chanakan, Prawan, Auemduan, Tontapha, Sarawut, Amornkitbamrung, Vittaya, Yenjai, Chavi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694366/
https://www.ncbi.nlm.nih.gov/pubmed/35424356
http://dx.doi.org/10.1039/d0ra10498a
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author Chuenban, Chindawadee
Sombatsri, Aonnicha
Sribuhom, Thurdpong
Pornchoo, Chanakan
Prawan, Auemduan
Tontapha, Sarawut
Amornkitbamrung, Vittaya
Yenjai, Chavi
author_facet Chuenban, Chindawadee
Sombatsri, Aonnicha
Sribuhom, Thurdpong
Pornchoo, Chanakan
Prawan, Auemduan
Tontapha, Sarawut
Amornkitbamrung, Vittaya
Yenjai, Chavi
author_sort Chuenban, Chindawadee
collection PubMed
description Six undescribed polyketides, 1–6, were discovered from the fruits of Knema globularia (Lam.) warb. Two known polyketides and three known lignans were also isolated. Cytotoxicities against HepG2 and KKU-M156 cells of all polyketides were evaluated. Compound 1 displayed the most cytotoxic activity against HepG2 and KKU-M156 cell lines with IC(50) values of 1.57 ± 0.37 and 1.78 ± 0.14 μg mL(−1), respectively. The structure of all isolates was identified using spectroscopic methods including NMR, IR, MS and ECD.
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spelling pubmed-86943662022-04-13 Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb Chuenban, Chindawadee Sombatsri, Aonnicha Sribuhom, Thurdpong Pornchoo, Chanakan Prawan, Auemduan Tontapha, Sarawut Amornkitbamrung, Vittaya Yenjai, Chavi RSC Adv Chemistry Six undescribed polyketides, 1–6, were discovered from the fruits of Knema globularia (Lam.) warb. Two known polyketides and three known lignans were also isolated. Cytotoxicities against HepG2 and KKU-M156 cells of all polyketides were evaluated. Compound 1 displayed the most cytotoxic activity against HepG2 and KKU-M156 cell lines with IC(50) values of 1.57 ± 0.37 and 1.78 ± 0.14 μg mL(−1), respectively. The structure of all isolates was identified using spectroscopic methods including NMR, IR, MS and ECD. The Royal Society of Chemistry 2021-01-20 /pmc/articles/PMC8694366/ /pubmed/35424356 http://dx.doi.org/10.1039/d0ra10498a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Chuenban, Chindawadee
Sombatsri, Aonnicha
Sribuhom, Thurdpong
Pornchoo, Chanakan
Prawan, Auemduan
Tontapha, Sarawut
Amornkitbamrung, Vittaya
Yenjai, Chavi
Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb
title Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb
title_full Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb
title_fullStr Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb
title_full_unstemmed Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb
title_short Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb
title_sort knecorticosanones c–h from the fruits of knema globularia (lam.) warb
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694366/
https://www.ncbi.nlm.nih.gov/pubmed/35424356
http://dx.doi.org/10.1039/d0ra10498a
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